Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T00972 Target Info
Target Name Human immunodeficiency virus Envelope glycoprotein gp120 (HIV gp120)
Synonyms Env polyprotein gp120 (33-511)
Target Type Successful Target
Gene Name HIV gp120
UniProt ID
ENV_HV1H2
Ligand General Information  Top
Ligand Name Phosphocholine Ligand Info
Canonical SMILES C[N+](C)(C)CCOP(=O)(O)O
InChI 1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p+1
InChIKey YHHSONZFOIEMCP-UHFFFAOYSA-O
PubChem Compound ID 1014
Drug Binding Sites of Target  Top
PDB ID: 6SNE      crystal structure of LN01 Fab in complex with an HIV-1 gp41 peptide
Method X-ray diffraction Resolution 3.90 Å Mutation No [1]
PDB Sequence
NWFNITNWLW
680
YIKLFIMIVG
690
GLVGLRIVFA
700
VLSVVNRVR
Residue
Distance (Å)
TRP680
3.383
TYR681
4.222
Residue
Distance (Å)
TRP680
3.049
PDB ID: 6SNC      crystal structure of LN01 Fab in complex with an HIV-1 gp41 peptide
Method X-ray diffraction Resolution 3.20 Å Mutation No [1]
PDB Sequence
NWFDITNWLW
680
YIKLFIMIV
Residue
Distance (Å)
TRP680
3.276
Residue
Distance (Å)
TYR681
3.206
References  Top
REF 1 Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01. Cell Host Microbe. 2019 Nov 13;26(5):623-637.e8.

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