Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00494 | Target Info | |||
| Target Name | ATP-binding cassette transporter A1 (ABCA1) | ||||
| Synonyms | Cholesterol mobilizing transporter ABCA1; Cholesterol efflux regulatory protein; CERP; ATP-binding cassette transporter (ABCA1) transmembrane protein; ATP-binding cassette sub-family A member 1; ATP-binding cassette 1; ABC1; ABC-1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | ABCA1 | ||||
| Biochemical Class | ABC transporter | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cholesterol | Ligand Info | |||
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C | ||||
| InChI | 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 | ||||
| InChIKey | HVYWMOMLDIMFJA-DPAQBDIFSA-N | ||||
| PubChem Compound ID | 5997 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7TBW The structure of ATP-bound ABCA1 | ||||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | Yes | [1] |
| PDB Sequence |
CWPQLRLLLW
12 KNLTFRRRQT22 CQLLLEVAWP32 LFIFLILISV42 RLSYPPYEQH52 ECHFPNKAMP 62 SAGTLPWVQG72 IICNANNPCF82 RYPTPGEAPG92 VVGNFNKSIV102 ARLFSDARRL 112 LLYSQKDTSM122 KDMRKVLRTL132 QQIKKSSSKS200 EEMIQLGDQE210 VSELCGLPRE 220 KLAAAERVLR230 SNMDILKPIL240 RTLNSTSPFP250 SKELAEATKT260 LLHSLGTLAQ 270 ELFSMRSWSD280 MRQEVMFLTS296 STQIYQAVSR306 IVCGHTPYCN356 DLMKNLESSP 366 LSRIIWKALK376 PLLVGKILYT386 PDTPATRQVM396 AEVNKTFQEL406 AVFHDLEGMW 416 EELSPKIWTF426 MENSQEMDLV436 RMLLDSRDND446 HFWEQQLDGL456 DWTAQDIVAF 466 LAKHPVYTWR485 EAFNETNQAI495 RTISRFMECV505 NLNKLEPIAT515 EVWLINKSME 525 LLDERKFWAG535 IVFTGITPGS545 IELPHHVKYK555 IRMDIDNVER565 TNKIKDGYWD 575 PGPRADPFED585 MRYVWGGFAY595 LQDVVEQAII605 RVLTGTEKKT615 GVYMQQMPYP 625 CYVDDIFLRV635 MSRSMPLFMT645 LAWIYSVAVI655 IKGIVYEKEA665 RLKETMRIMG 675 LDNSILWFSW685 FISSLIPLLV695 SAGLLVVILK705 LGNLLPYSDP715 SVVFVFLSVF 725 AVVTILQCFL735 ISTLFSRANL745 AAACGGIIYF755 TLYLPYVLCV765 AWRDYVGFTL 775 KIFASLLSPV785 AFGFGCEYFA795 LFEEQGIGVQ805 WDNLFESPVE815 EDGFNLTTSV 825 SMMLFDTFLY835 GVMTWYIEAV845 FPGQYGIPRP855 WYFPCEPTHL895 KLGVSIQNLV 905 KVYRDGMKVA915 VDGLALNFYE925 GQITSFLGHN935 GAGKTTTMSI945 LTGLFPPTSG 955 TAYILGKDIR965 SEMSTIRQNL975 GVCPQHNVLF985 DMLTVEEHIW995 FYARLKGLSE 1005 KHVKAEMEQM1015 ALDVGLPSSK1025 LKSKTSQLSG1035 GMQRKLSVAL1045 AFVGGSKVVI 1055 LDQPTAGVDP1065 YSRRGIWELL1075 LKYRQGRTII1085 LSTHHMDEAD1095 VLGDRIAIIS 1105 HGKLCCVGSS1115 LFLKNQLGTG1125 YYLTLVKSAI1183 SNLIRKHVSE1193 ARLVEDIGHE 1203 LTYVLPAFVE1220 LFHEIDDRIS1235 SYGISETTLE1245 EIFLKVAEES1255 GKGSYQVKGW 1322 KLTQQQFVAL1332 LWKRLLIARR1342 SRKGFFAQIV1352 LPAVFVCIAL1362 VFSLIVPPFG 1372 KYPSLELQPW1382 MYNEQYTFVS1392 NDAPEDTGTL1402 ELLNALTKDP1412 GFGTRCMEGN 1422 PIPDTPCQAG1432 EEEWTTAPVP1442 QTIMDLFQNG1452 NWTMQNPSPA1462 CQCSKMLPVC 1477 PPGAGGLPPP1487 QRKQNTADIL1497 QDLTGRNISD1507 YLVKTYVQII1517 AKSLKNKIWV 1527 NEFRYGGFSL1537 GVSNPSQEVN1552 DAIKQMKKHL1562 KLAKDSSADR1572 FLNSLGRFMT 1582 GLDTKNNVKV1592 WFNNKGWHAI1602 SSFLNVINNA1612 ILRANLQKGE1622 NPSHYGITAF 1632 NHPLNLTKQQ1642 LSEVALMTTS1652 VDVLVSICVI1662 FAMSFVPASF1672 VVFLIQERVS 1682 KAKHLQFISG1692 VKPVIYWLSN1702 FVWDMCNYVV1712 PATLVIIIFI1722 CFQQKSYVSS 1732 TNLPVLALLL1742 LLYGWSITPL1752 MYPASFVFKI1762 PSTAYVVLTS1772 VNLFIGINGS 1782 VATFVLELFT1792 DNKLNNINDI1802 LKSVFLIFPH1812 FCLGRGLIDM1822 VKNQAMADAL 1832 ERVSPLSWDL1848 VGRNLFAMAV1858 EGVVFFLITV1868 LIQYRFFIDE1891 DEDVRRERQR 1901 ILDGGGQNDI1911 LEIKELTKIY1921 RRKRKPAVDR1931 ICVGIPPGEC1941 FGLLGVNGAG 1951 KSSTFKMLTG1961 DTTVTRGDAF1971 LNKNSILSNI1981 HEVHQNMGYC1991 PQFDAITELL 2001 TGREHVEFFA2011 LLRGVPEKEV2021 GKVGEWAIRK2031 LGLVKYGEKY2041 AGNYSGGNKR 2051 KLSTAMALIG2061 GPPVVFLDQP2071 TTGMDPKARR2081 FLWNCALSVV2091 KEGRSVVLTS 2101 HSMEECEALC2111 TRMAIMVNGR2121 FRCLGSVQHL2131 KNRFGDGYTI2141 VVRIDLKPVQ 2156 DFFGLAFPGS2166 VLKEKHRNML2176 QYQLPSSLSS2186 LARIFSILSQ2196 SKKRLHIEDY 2206 SVSQTTLDQV2216 FVNFAKDQ
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| PDB ID: 7TC0 The structure of human ABCA1 in digitonin | ||||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | No | [1] |
| PDB Sequence |
CWPQLRLLLW
12 KNLTFRRRQT22 CQLLLEVAWP32 LFIFLILISV42 RLSYPPYEQH52 ECHFPNKAMP 62 SAGTLPWVQG72 IICNANNPCF82 RYPTPGEAPG92 VVGNFNKSIV102 ARLFSDARRL 112 LLYSQKDTSM122 KDMRKVLRTL132 QPSKELAEAT258 KTLLHSLGTL268 AQELFSMRSW 278 SDMRQEVMFL288 TSSTQIYQAV304 SRIVCGHDNS350 TTPYCNDLMK360 NLESSPLSRI 370 IWKALKPLLV380 GKILYTPDTP390 ATRQVMAEVN400 KTFQELAVFH410 DLEGMWEELS 420 PKIWTFMENS430 QEMDLVRMLL440 DSRDNDHFWE450 QQLDGLDWTA460 QDIVAFLAKH 470 PVYTWREAFN489 ETNQAIRTIS499 RFMECVNLNK509 LEPIATEVWL519 INKSMELLDE 529 RKFWAGIVFT539 GITPGSIELP549 HHVKYKIRMD559 IDNVERTNKI569 KDGYWDPGPR 579 ADPFEDMRYV589 WGGFAYLQDV599 VEQAIIRVLT609 GTEKKTGVYM619 QQMPYPCYVD 629 DIFLRVMSRS639 MPLFMTLAWI649 YSVAVIIKGI659 VYEKEARLKE669 TMRIMGLDNS 679 ILWFSWFISS689 LIPLLVSAGL699 LVVILKLGNL709 LPYSDPSVVF719 VFLSVFAVVT 729 ILQCFLISTL739 FSRANLAAAC749 GGIIYFTLYL759 PYVLCVAWRD769 YVGFTLKIFA 779 SLLSPVAFGF789 GCEYFALFEE799 QGIGVQWDNL821 TTSVSMMLFD831 TFLYGVMTWY 841 IEAVFPGQYG851 IPRPCMEEEP892 THLKLGVSIQ902 NLVKVYDGLA920 LNFYEGQITS 930 FLGHNGAGKT940 TTMSILTGLF950 PPTSGTAYIL960 GKDIRSEMST970 IRQNLGVCPQ 980 HNVLFDMLTV990 EEHIWFYARL1000 KGLSEKHVKA1010 EMEQMALDVG1020 LPSSKLKSKT 1030 SQLSGGMQRK1040 LSVALAFVGG1050 SKVVILDEPT1060 AGVDPYSRRG1070 IWELLLKYRQ 1080 GRTIILSTHH1090 MDEADVLGDR1100 IAIISHGKLC1110 CVGSSLFLKN1120 QLGTGYYLTL 1130 VKDVSAISNL1186 IRKHVSEARL1196 VEDIGHELTY1206 VLPYEAAKEG1216 AFVELFHEID 1226 DRLSDLGISS1236 YGISETTLEE1246 IFLKVAGKGS1316 YQVKGWKLTQ1326 QQFVALLWKR 1336 LLIARRSRKG1346 FFAQIVLPAV1356 FVCIALVFSL1366 IVPPFGKYPS1376 LELQPWMYNE 1386 QYTFVSNDAP1396 EDTGTLELLN1406 ALTKDPGFGT1416 RCMEGNPIPD1426 TPCQAGEEEW 1436 TTAPVPQTIM1446 DLFQNGNWTM1456 QNPSPACQCS1466 SDKIKKMLPV1476 CPPGAGGLPP 1486 PQRKQNTADI1496 LQDLTGRNIS1506 DYLVKTYVQI1516 IAKSLKNKIW1526 VNEFRYGGFS 1536 LGVSQEVNDA1554 IKQMKKHLKL1564 AKDSSADRFL1574 NSLGRFMTGL1584 DTKNNVKVWF 1594 NNKGWHAISS1604 FLNVINNAIL1614 RANLQKGENP1624 SHYGITAFNH1634 PLNLTKQQLS 1644 EVALMTTSVD1654 VLVSICVIFA1664 MSFVPASFVV1674 FLIQERVSKA1684 KHLQFISGVK 1694 PVIYWLSNFV1704 WDMCNYVVPA1714 TLVIIIFICF1724 QQKSYVSSTN1734 LPVLALLLLL 1744 YGWSITPLMY1754 PASFVFKIPS1764 TAYVVLTSVN1774 LFIGINGSVA1784 TFVNDILKSV 1806 FLIFPHFCLG1816 RGLIDMVKNQ1826 AMADALERFG1836 ENRFVSPLSW1846 DLVGRNLFAM 1856 AVEGVVFFLI1866 TVLIQYRFGI1936 PPGECFGLLG1946 VHQNMGYCPQ1993 FDAITELLTG 2003 REHVEFFALL2013 RGVPEKEVGK2023 VGEWAIRKLG2033 LVKYGEKYAG2043 NYSGGNKRKL 2053 STAMALIGGP2063 PVVFLDEPTT2073 GMDPKARRFL2083 WNCALSVVKE2093 GRSVVLTSHS 2103 MEECEALCTR2113 MAIMVNGRFR2123 CLGSVQHLKN2133 RFGDGYTIVV2143 RIAGSNPDLK 2153 PVQDFFGLAF2163 PGSVLKEKHR2173 NMLQYQLPSS2183 LSSLARIFSI2193 LSQSKKRLHI 2203 EDYSVSQTTL2213 DQVFVNFAKD2223 Q
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GLN24
3.601
LEU272
3.961
PHE273
4.961
TRP278
3.765
SER279
3.735
ARG282
4.985
TRP458
3.689
PHE466
3.615
TYR482
3.612
ALA487
4.521
ILE649
4.943
TYR650
4.449
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| PDB ID: 7TBY The structure of human ABCA1 in nanodisc | ||||||
| Method | Electron microscopy | Resolution | 4.00 Å | Mutation | No | [1] |
| PDB Sequence |
CWPQLRLLLW
12 KNLTFRRRQT22 CQLLLEVAWP32 LFIFLILISV42 RLSYPPYEQH52 ECHFPNKAMP 62 SAGTLPWVQG72 IICNANNPCF82 RYPTPGEAPG92 VVGNFNKSIV102 ARLFSDARRL 112 LLYSQKDTSM122 KDMRKVLRTL132 QQPSKELAEA257 TKTLLHSLGT267 LAQELFSMRS 277 WSDMRQEVMF287 LTSSTQIYQA303 VSRIVCGHPF346 YDNSTTPYCN356 DLMKNLESSP 366 LSRIIWKALK376 PLLVGKILYT386 PDTPATRQVM396 AEVNKTFQEL406 AVFHDLEGMW 416 EELSPKIWTF426 MENSQEMDLV436 RMLLDSRDND446 HFWEQQLDGL456 DWTAQDIVAF 466 LAKHPVYTWR485 EAFNETNQAI495 RTISRFMECV505 NLNKLEPIAT515 EVWLINKSME 525 LLDERKFWAG535 IVFTGITPGS545 IELPHHVKYK555 IRMDIDNVER565 TNKIKDGYWD 575 PGPRADPFED585 MRYVWGGFAY595 LQDVVEQAII605 RVLTGTEKKT615 GVYMQQMPYP 625 CYVDDIFLRV635 MSRSMPLFMT645 LAWIYSVAVI655 IKGIVYEKEA665 RLKETMRIMG 675 LDNSILWFSW685 FISSLIPLLV695 SAGLLVVILK705 LGNLLPYSDP715 SVVFVFLSVF 725 AVVTILQCFL735 ISTLFSRANL745 AAACGGIIYF755 TLYLPYVLCV765 AWRDYVGFTL 775 KIFASLLSPV785 AFGFGCEYFA795 LFEEQGIGVQ805 WDNNLTTSVS826 MMLFDTFLYG 836 VMTWYIEAVF846 PGQYGIPRCM888 EEEPTHLKLG898 VSIQNLVKVY908 LALNFYEGQI 928 TSFLGHNGAG938 KTTTMSILTG948 LFPPTSGTAY958 ILGKDIRSEM968 STIRQNLGVC 978 PQHNVLFDML988 TVEEHIWFYA998 RLKGLSEKHV1008 KAEMEQMALD1018 VGLPSSKLKS 1028 KTSQLSGGMQ1038 RKLSVALAFV1048 GGSKVVILDE1058 PTAGVDPYSR1068 RGIWELLLKY 1078 RQGRTIILST1088 HHMDEADVLG1098 DRIAIISHGK1108 LCCVGSSLFL1118 KNQLGTGYYL 1128 TLVKVSAISN1185 LIRKHVSEAR1195 LVEDIGHELT1205 YVLPYEGAFV1219 ELFHEIDDRL 1229 SDLGISSYGI1239 SETTLEEIFL1249 KVAWKLTQQQ1328 FVALLWKRLL1338 IARRSRKGFF 1348 AQIVLPAVFV1358 CIALVFSLIV1368 PPFGKYPSLE1378 LQPWMYNEQY1388 TFVSNDAPED 1398 TGTLELLNAL1408 TKDPGFGTRC1418 MEGNPIPDTP1428 CQAGEEEWTT1438 APVPQTIMDL 1448 FQNGNWTMQN1458 PSPACQCSSD1468 KIKKMLPVCP1478 PGAGGLPPPQ1488 RKQNTADILQ 1498 DLTGRNISDY1508 LVKTYVQIIA1518 KSLKNKIWVN1528 EFRYGGFSLG1538 VSSQEVNDAI 1555 KQMKKHLKLA1565 KDSSADRFLN1575 SLGRFMTGLD1585 TKNNVKVWFN1595 NKGWHAISSF 1605 LNVINNAILR1615 ANLQKGENPS1625 HYGITAFNHP1635 LNLTKQQLSE1645 VALMTTSVDV 1655 LVSICVIFAM1665 SFVPASFVVF1675 LIQERVSKAK1685 HLQFISGVKP1695 VIYWLSNFVW 1705 DMCNYVVPAT1715 LVIIIFICFQ1725 QKSYVSSTNL1735 PVLALLLLLY1745 GWSITPLMYP 1755 ASFVFKIPST1765 AYVVLTSVNL1775 FIGINGSVAT1785 FVINDILKSV1806 FLIFPHFCLG 1816 RGLIDMVKNQ1826 AMADALERFG1836 ENRFVSPLSW1846 DLVGRNLFAM1856 AVEGVVFFLI 1866 TVLIQYRFVD1930 RICVGIPPGE1940 CFGLLGVNGA1950 GKSSTFKMLT1960 EVHQNMGYCP 1992 QFDAITELLT2002 GREHVEFFAL2012 LRGVPEKEVG2022 KVGEWAIRKL2032 GLVKYGEKYA 2042 GNYSGGNKRK2052 LSTAMALIGG2062 PPVVFLDEPT2072 TGMDPKARRF2082 LWNCALSVVK 2092 EGRSVVLTSH2102 SMEECEALCT2112 RMAIMVNGRF2122 RCLGSVQHLK2132 NRFGDGYTIV 2142 VRIPDLKPVQ2156 DFFGLAFPGS2166 VLKEKHRNML2176 QYQLPSSLSS2186 LARIFSILSQ 2196 SKKRLHIEDY2206 SVSQTTLDQV2216 FVNFAKDQ
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| PDB ID: 7TBZ The structure of ABCA1 Y482C | ||||||
| Method | Electron microscopy | Resolution | 4.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
CWPQLRLLLW
12 KNLTFRRRQT22 CQLLLEVAWP32 LFIFLILISV42 RLSYPPYEQH52 ECHFPNKAMP 62 SAGTLPWVQG72 IICNANNPCF82 RYPTPGEAPG92 VVGNFNKSIV102 ARLFSDARRL 112 LLYSQKDTSM122 KDMRKVLRTL132 QQPSKELAEA257 TKTLLHSLGT267 LAQELFSMRS 277 WSDMRQEVMF287 LTSSTQIYQA303 VSRIVCGHPF346 YDNSTTPYCN356 DLMKNLESSP 366 LSRIIWKALK376 PLLVGKILYT386 PDTPATRQVM396 AEVNKTFQEL406 AVFHDLEGMW 416 EELSPKIWTF426 MENSQEMDLV436 RMLLDSRDND446 HFWEQQLDGL456 DWTAQDIVAF 466 LAKHPVCTWR485 EAFNETNQAI495 RTISRFMECV505 NLNKLEPIAT515 EVWLINKSME 525 LLDERKFWAG535 IVFTGITPGS545 IELPHHVKYK555 IRMDIDNVER565 TNKIKDGYWD 575 PGPRADPFED585 MRYVWGGFAY595 LQDVVEQAII605 RVLTGTEKKT615 GVYMQQMPYP 625 CYVDDIFLRV635 MSRSMPLFMT645 LAWIYSVAVI655 IKGIVYEKEA665 RLKETMRIMG 675 LDNSILWFSW685 FISSLIPLLV695 SAGLLVVILK705 LGNLLPYSDP715 SVVFVFLSVF 725 AVVTILQCFL735 ISTLFSRANL745 AAACGGIIYF755 TLYLPYVLCV765 AWRDYVGFTL 775 KIFASLLSPV785 AFGFGCEYFA795 LFEEQGIGVQ805 WDNNLTTSVS826 MMLFDTFLYG 836 VMTWYIEAVF846 PGQYGIPRCM888 EEEPTHLKLG898 VSIQNLVKVY908 LALNFYEGQI 928 TSFLGHNGAG938 KTTTMSILTG948 LFPPTSGTAY958 ILGKDIRSEM968 STIRQNLGVC 978 PQHNVLFDML988 TVEEHIWFYA998 RLKGLSEKHV1008 KAEMEQMALD1018 VGLPSSKLKS 1028 KTSQLSGGMQ1038 RKLSVALAFV1048 GGSKVVILDE1058 PTAGVDPYSR1068 RGIWELLLKY 1078 RQGRTIILST1088 HHMDEADVLG1098 DRIAIISHGK1108 LCCVGSSLFL1118 KNQLGTGYYL 1128 TLVKVSAISN1185 LIRKHVSEAR1195 LVEDIGHELT1205 YVLPYEGAFV1219 ELFHEIDDRL 1229 SDLGISSYGI1239 SETTLEEIFL1249 KVAWKLTQQQ1328 FVALLWKRLL1338 IARRSRKGFF 1348 AQIVLPAVFV1358 CIALVFSLIV1368 PPFGKYPSLE1378 LQPWMYNEQY1388 TFVSNDAPED 1398 TGTLELLNAL1408 TKDPGFGTRC1418 MEGNPIPDTP1428 CQAGEEEWTT1438 APVPQTIMDL 1448 FQNGNWTMQN1458 PSPACQCSSD1468 KIKKMLPVCP1478 PGAGGLPPPQ1488 RKQNTADILQ 1498 DLTGRNISDY1508 LVKTYVQIIA1518 KSLKNKIWVN1528 EFRYGGFSLG1538 VSSQEVNDAI 1555 KQMKKHLKLA1565 KDSSADRFLN1575 SLGRFMTGLD1585 TKNNVKVWFN1595 NKGWHAISSF 1605 LNVINNAILR1615 ANLQKGENPS1625 HYGITAFNHP1635 LNLTKQQLSE1645 VALMTTSVDV 1655 LVSICVIFAM1665 SFVPASFVVF1675 LIQERVSKAK1685 HLQFISGVKP1695 VIYWLSNFVW 1705 DMCNYVVPAT1715 LVIIIFICFQ1725 QKSYVSSTNL1735 PVLALLLLLY1745 GWSITPLMYP 1755 ASFVFKIPST1765 AYVVLTSVNL1775 FIGINGSVAT1785 FVINDILKSV1806 FLIFPHFCLG 1816 RGLIDMVKNQ1826 AMADALERFG1836 ENRFVSPLSW1846 DLVGRNLFAM1856 AVEGVVFFLI 1866 TVLIQYRFVD1930 RICVGIPPGE1940 CFGLLGVNGA1950 GKSSTFKMLT1960 EVHQNMGYCP 1992 QFDAITELLT2002 GREHVEFFAL2012 LRGVPEKEVG2022 KVGEWAIRKL2032 GLVKYGEKYA 2042 GNYSGGNKRK2052 LSTAMALIGG2062 PPVVFLDEPT2072 TGMDPKARRF2082 LWNCALSVVK 2092 EGRSVVLTSH2102 SMEECEALCT2112 RMAIMVNGRF2122 RCLGSVQHLK2132 NRFGDGYTIV 2142 VRIPDLKPVQ2156 DFFGLAFPGS2166 VLKEKHRNML2176 QYQLPSSLSS2186 LARIFSILSQ 2196 SKKRLHIEDY2206 SVSQTTLDQV2216 FVNFAKDQ
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .A:67 or .A:70 or .A:106 or .A:288 or .A:409 or .A:497 or .A:498 or .A:501 or .A:502 or .A:1580; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7ROQ Alternative Structure of Human ABCA1 | ||||||
| Method | Electron microscopy | Resolution | 4.10 Å | Mutation | No | [2] |
| PDB Sequence |
CWPQLRLLLW
12 KNLTFRRRQT22 CQLLLEVAWP32 LFIFLILISV42 RLSYPPYEQH52 ECHFPNKAMP 62 SAGTLPWVQG72 IICNANNPCF82 RYPTPGEAPG92 VVGNFNKSIV102 ARLFSDARRL 112 LLYSQKDTSM122 KDMRKVLRTL132 QQIKKSSSNL142 KLQDFLVDNE152 TFSGFLYHNL 162 SLPKSTVDKM172 LRSKSEEMIQ205 LGDQEVSELC215 GLPREKLAAA225 ERVLRSNMDI 235 LKPILRTLNS245 TSPFPSKELA255 EATKTLLHSL265 GTLAQELFSM275 RSWSDMRQEV 285 MFLTNVNSSS295 SSTQIYQAVS305 RIVCGHPTPY354 CNDLMKNLES364 SPLSRIIWKA 374 LKPLLVGKIL384 YTPDTPATRQ394 VMAEVNKTFQ404 ELAVFHDLEG414 MWEELSPKIW 424 TFMENSQEMD434 LVRMLLDSRD444 NDHFWEQQLD454 GLDWTAQDIV464 AFLAKHPEDV 474 QSSNGSVYTW484 REAFNETNQA494 IRTISRFMEC504 VNLNKLEPIA514 TEVWLINKSM 524 ELLDERKFWA534 GIVFTGITPG544 SIELPHHVKY554 KIRMDIDNVE564 RTNKIKDGYW 574 DPGPRADPFE584 DMRYVWGGFA594 YLQDVVEQAI604 IRVLTGTEKK614 TGVYMQQMPY 624 PCYVDDIFLR634 VMSRSMPLFM644 TLAWIYSVAV654 IIKGIVYEKE664 ARLKETMRIM 674 GLDNSILWFS684 WFISSLIPLL694 VSAGLLVVIL704 KLGNLLPYSD714 PSVVFVFLSV 724 FAVVTILQCF734 LISTLFSRAN744 LAAACGGIIY754 FTLYLPYVLC764 VAWQDYVGFT 774 LKIFASLLSP784 VAFGFGCEYF794 ALFEEQGFNL821 TTSVSMMLFD831 TFLYGVMTWY 841 IEAVFICMEE890 EPTHLKLGVS900 IQNLVKVDGL919 ALNFYEGQIT929 SFLGHNGAGK 939 TTTMSILTGL949 FPPTSGTAYI959 LGKDIRSEMS969 TIRQNLGVCP979 QHNVLFDMLT 989 VEEHIWFYAR999 LKGLSEKHVK1009 AEMEQMALDV1019 GLSSKLKSKT1030 SQLSGGMQRK 1040 LSVALAFVGG1050 SKVVILDEPT1060 AGVDPYSRRG1070 IWELLLKYRQ1080 GRTIILSTHH 1090 MDEADVLGDR1100 IAIISHGKLC1110 CVGSSLFLKN1120 QLGTGYYLTL1130 VKKLTIDVSA 1182 ISNLIRKHVS1192 EARLVEDIGH1202 ELTYVLPYEA1212 AKEGAFVELF1222 HEIDDRLSDL 1232 GISSYGISET1242 TLEEIFLKVA1252 WKLTQQQFVA1331 LLWKRLLIAR1341 RSRKGFFAQI 1351 VLPAVFVCIA1361 LVFSLIVPPF1371 GKYPSLELQP1381 WMYNEQYTFV1391 SNDAPEDTGT 1401 LELLNALTKD1411 PGFGTRCMEG1421 NPIPDTPCQA1431 GEEEWTTAPV1441 PQTIMDLFQN 1451 GNWTMQNPSP1461 ACQCSSDKIK1471 KMLPVCPPGA1481 GGLPPPQRKQ1491 NTADILQDLT 1501 GRNISDYLVK1511 TYVQIIAKSL1521 KNKIWVNEFR1531 YGGFSLGVSN1541 TQALPPSQEV 1551 NDAIKQMKKH1561 LKLAKDSSAD1571 RFLNSLGRFM1581 TGLDTKNNVK1591 VWFNNKGWHA 1601 ISSFLNVINN1611 AILRANLQKG1621 ENPSHYGITA1631 FNHPLNLTKQ1641 QLSEVALMTT 1651 SVDVLVSICV1661 IFAMSFVPAS1671 FVVFLIQERV1681 SKAKHLQFIS1691 GVKPVIYWLS 1701 NFVWDMCNYV1711 VPATLVIIIF1721 ICFQQKSYVS1731 STNLPVLALL1741 LLLYGWSITP 1751 LMYPASFVFK1761 IPSTAYVVLT1771 SVNLFIGIIN1800 DILKSVFLIF1810 PHFCLGRGLI 1820 DMVKNQAMAD1830 ALERFGENRF1840 VSPLSWDLVG1850 RNLFAMAVEG1860 VVFFLITVLI 1870 QYRFFGYCPQ1993 FDAITELLTG2003 REHVEFFALL2013 RGVPEKEVGK2023 VGEWAIRKLG 2033 LVKYGEKYAG2043 NYSGGNKRKL2053 STAMALIGGP2063 PVVFLDEPTT2073 GMDPKARRFL 2083 WNCALSVVKE2093 GRSVVLTSHS2103 MEECEALCTG2126 SVQHLKNRFG2136 DGYTIVVRIA 2146 SNPDLKPVQD2157 FFGLAFPGSV2167 LKEKHRNMLQ2177 YQLPSSSLAR2189 IFSILSQSKK 2199 RLHIEDYSVS2209 QTTLDQVFVN2219 F
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .A:745 or .A:752 or .A:1347 or .A:1349 or .A:1353 or .A:1667 or .A:1764 or .A:1765 or .A:1767 or .A:1768 or .A:1769 or .A:1771 or .A:1772; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
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| REF 1 | Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states. Nat Cardiovasc Res. 2022;1(3):238-245. | ||||
| REF 2 | Refined ABCA1 with Domain-swapped Regulatory Domains | ||||
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