Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99989 | Target Info | |||
| Target Name | Casein kinase I epsilon (CSNK1E) | ||||
| Synonyms | Casein kinase I isoform epsilon; CKIe; CKI-epsilon | ||||
| Target Type | Successful Target | ||||
| Gene Name | CSNK1E | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: PF-4800567 | Ligand Info | |||||
| Structure Description | crystal structure of ck1e in complex with PF4800567 | PDB:4HNI | ||||
| Method | X-ray diffraction | Resolution | 2.74 Å | Mutation | No | [1] |
| PDB Sequence |
LRVGNKYRLG
12 RKIGSGSFGD22 IYLGANIASG32 EEVAIKLECV42 HIESKFYKMM59 QGGVGIPSIK 69 WCGAEGDYNV79 MVMELLGPSL89 EDLFNFCSRK99 FSLKTVLLLA109 DQMISRIEYI 119 HSKNFIHRDV129 KPDNFLMGLG139 KKGNLVYIID149 FGLAKKYRDA159 RTHQHIPYRE 169 NKNLTGTARY179 ASINTHLGIE189 QSRRDDLESL199 GYVLMYFNLG209 SLPWQGLKAA 219 TKRQKYERIS229 EKKMSTPIEV239 LCKGYPSEFS249 TYLNFCRSLR259 FDDKPDYSYL 269 RQLFRNLFHR279 QGFSYDYVFD289 WNML
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. J Med Chem. 2012 Nov 26;55(22):10307-11. | ||||
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