Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T99840 Target Info
Target Name Gamma-secretase (GS)
Synonyms Presenilin-stabilization factor-like; PSFL; Aph-1beta
Target Type Successful Target
Gene Name APH1A; APH1B; NCSTN; PSENEN; PSEN1
UniProt ID
APH1A_HUMAN; APH1B_HUMAN; PEN2_HUMAN; NICA_HUMAN; PSN1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Cholesterol Ligand Info
Structure Description Recognition of the Amyloid Precursor Protein by Human gamma-secretase PDB:6IYC
Method Electron microscopy Resolution 2.60 Å Mutation Yes [1]
PDB Sequence
GAAVFFGCTF
11
VAFGPAFALF
21
LITVAGDPLR
31
VIILVAGAFF
41
WLVSLLLASV
51

VWFILVHVTD
61
RSDARLQYGL
71
LIFGAAVSVL
81
LQEVFRFAYY
91
KLLKKADEGL
101

ASLSEDGRSP
111
ISIRQMAYVS
121
GLSFGIISGV
131
FSVINILADA
141
LGPGVVGIHG
151

DSPYYFLTSA
161
FLTAAIILLH
171
TFWGVVFFDA
181
CERRRYWALG
191
LVVGSHLLTS
201

GLTFLNPWYE
211
ASLLPIYAVT
221
VSMGLWAFIT
231
AGGSLRSIQR
241
SLL
Residue
Distance (Å)
ARG66
3.518
TYR69
3.350
ILE73
4.010
SER153
4.583
TYR155
3.554
THR159
4.240
PHE162
3.867
ARG186
4.260
TRP188
3.996
LEU192
3.698
LEU199
4.360
GLY202
3.240
Residue
Distance (Å)
LEU203
4.845
PHE205
3.591
LEU206
3.721
TYR210
3.583
GLU211
4.165
LEU214
1.494
LEU215
3.585
SER223
3.169
MET224
4.981
TRP227
1.430
ILE230
4.185
THR231
5.000
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 Recognition of the amyloid precursor protein by human Gamma-secretase. Science. 2019 Feb 15;363(6428):eaaw0930.

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