Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99557 | Target Info | |||
| Target Name | T-cell receptor beta constant 1 (TRBC1) | ||||
| Synonyms | TCRBC1; BV05S1J2.2 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | TRBC1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 1-Deoxy-1-[6-(Hydroxymethyl)-2,4-Dioxo-3,4-Dihydropteridin-8(2h)-Yl]-D-Arabinitol | Ligand Info | |||||
| Structure Description | Crystal structure of a human MAIT TCR in complex with a bacterial antigen bound to humanized bovine MR1 | PDB:4LCC | ||||
| Method | X-ray diffraction | Resolution | 3.26 Å | Mutation | Yes | [1] |
| PDB Sequence |
AGVTQTPKFQ
11 VLKTGQSMTL21 QCAQDMNHNS31 MYWYRQDPGM41 GLRLIYYSAS51 EGTTDKGEVP 61 NGYNVSRLNK71 REFSLRLESA81 APSQTSVYFC91 ASSVWTGEGS101 GELFFGEGSR 111 LTVLEDLKNV121 FPPEVAVFEP131 SEAEISHTQK141 ATLVCLATGF151 YPDHVELSWW 161 VNGKEVHSGV171 CTDPQPLKEQ181 PALNDSRYAL191 SSRLRVSATF201 WQNPRNHFRC 211 QVQFYGLSEN221 DEWKPVTQIV236 SAEAWGRA
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | MAIT recognition of a stimulatory bacterial antigen bound to MR1. J Immunol. 2013 Nov 15;191(10):5268-77. | ||||
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