Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99402 | Target Info | |||
| Target Name | Metabotropic glutamate receptor 4 (mGluR4) | ||||
| Synonyms | mGluR4; Group III metabotropic glutamate receptor 4; GPRC1D | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | GRM4 | ||||
| Biochemical Class | GPCR glutamate | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: L-serine-O-phosphate | Ligand Info | |||||
| Structure Description | Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu4 | PDB:7E9H | ||||
| Method | Electron microscopy | Resolution | 4.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
NSIRIDGDIT
50 LGGLFPVHGR60 GSEGKPCGEL70 KKEKGIHRLE80 AMLFALDRIN90 NDPDLLPNIT 100 LGARILDTCS110 RDTHALEQSL120 TFVQALIERV150 VGVIGASGSS160 VSIMVANILR 170 LFKIPQISYA180 STAPDLSDNS190 RYDFFSRVVP200 SDTYQAQAMV210 DIVRALKWNY 220 VSTVASEGSY230 GESGVEAFIQ240 KSREDGGVCI250 AQSVKIPREP260 KAGEFDKIIR 270 RLLETSNARA280 VIIFANEDDI290 RRVLEAARRA300 NQTGHFFWMG310 SDSWGSKIAP 320 VLHLEEVAEG330 AVTILPKRMS340 VRGFDRYFSS350 RTLDNNRRNI360 WFAEFWEDNF 370 HCKLVKKCTN390 RERIGQDSAY400 EQEGKVQFVI410 DAVYAMGHAL420 HAMHRDLCPG 430 RVGLCPRMDP440 VDGTQLLKYI450 RNVNFSGIAG460 NPVTFNENGD470 APGRYDIYQY 480 QLRAEYKVIG493 SWTDHLHLRI503 QQLPRSICSL522 PCQPGERKKT532 VKGMPCCWHC 542 EPCTGYQYQV552 DRYTCKTCPY562 DMRPTENRTG572 CRPIPIIKLE582 WGSPWAVLPL 592 FLAVVGIAAT602 LFVVITFVRY612 NDTPIVKASG622 RELSYVLLAG632 IFLCYATTFL 642 MIAEPDLGTC652 SLRRIFLGLG662 MSISYAALLT672 KTNRIYRIFE682 QGKRSVSAPR 692 FISPASQLAI702 TFSLISLQLL712 GICVWFVVDP722 SHSVVDFQDQ732 RTLDPRFARG 742 VLKCDISDLS752 LICLLGYSML762 LMVTCTVYAI772 KTRGVPETFN782 EAKPIGFTMY 792 TTCIVWLAFI802 PIFFGTSQSA812 DKLYIQTTTL822 TVSVSLSASV832 SLGMLYMPKV 842 YIILFH
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structures of G(i)-bound metabotropic glutamate receptors mGlu2 and mGlu4. Nature. 2021 Jun;594(7864):583-588. | ||||
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