Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99295 | Target Info | |||
| Target Name | Phosphatidylinositol-4-kinase alpha (PI4KA) | ||||
| Synonyms | PtdIns-4-kinase alpha; PI4K-alpha; PI4-kinase alpha | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PI4KA | ||||
| Biochemical Class | PI3/PI4-kinase family. Type III PI4K subfamily | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 5-[2-amino-3-(4-morpholin-4-ylphenyl)benzimidazol-5-yl]-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide | Ligand Info | |||||
| Structure Description | Human PI4KIIIa lipid kinase complex | PDB:6BQ1 | ||||
| Method | Electron microscopy | Resolution | 3.60 Å | Mutation | No | [1] |
| PDB Sequence |
.
|
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|
|
GLN1796[A]
4.451
SER1797[A]
3.329
ALA1798[A]
4.625
PRO1802[A]
3.847
LEU1804[A]
4.552
ILE1848[A]
4.269
LYS1850[A]
2.590
ASP1853[A]
4.790
TYR1884[A]
3.736
ILE1896[A]
2.656
GLU1897[A]
3.223
CYS1898[A]
3.195
ILE1899[A]
2.751
PRO1900[A]
4.953
ASP1901[A]
2.681
CYS1902[A]
4.614
THR1903[A]
3.649
SER1904[A]
2.690
GLN1907[A]
2.650
GLY1961[A]
4.242
ASN1962[A]
2.603
MET1964[A]
2.634
ILE1974[A]
3.169
GLN1796[E]
3.749
SER1797[E]
3.380
ALA1798[E]
4.654
LYS1800[E]
4.860
PRO1802[E]
3.863
LEU1804[E]
4.547
ILE1848[E]
4.373
LYS1850[E]
2.680
ASP1853[E]
4.747
ASP1858[E]
4.853
TYR1884[E]
3.241
ILE1896[E]
2.802
GLU1897[E]
3.005
CYS1898[E]
3.359
ILE1899[E]
2.614
PRO1900[E]
4.838
ASP1901[E]
3.187
THR1903[E]
4.029
SER1904[E]
2.757
GLN1907[E]
3.274
GLY1961[E]
4.290
ASN1962[E]
2.890
MET1964[E]
2.554
ILE1974[E]
3.135
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Architecture of the human PI4KIIIAlpha lipid kinase complex. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13720-13725. | ||||
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