Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T98642 | Target Info | |||
| Target Name | PDZ binding kinase (PBK) | ||||
| Synonyms | TOPK; T-LAK cell-originated protein kinase; Spermatogenesis-related protein kinase; SPK protein; PDZ-binding kinase; Nori-3; MAPKK-like protein kinase; Lymphokine-activated killer T-cell-originated protein kinase; Cancer/testis antigen 84; CT84 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PBK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: P-coumaric acid | Ligand Info | |||||
| Structure Description | Crystal structure of PDZ-binding kinase | PDB:5J0A | ||||
| Method | X-ray diffraction | Resolution | 2.74 Å | Mutation | Yes | [1] |
| PDB Sequence |
> Chain A
STPTINIPAS 32 PFMQKLGFGT42 GVNVYLMKRS52 PRGLSHSPWA62 VKKINPICND72 HYRSVYQKRL 82 MDEAKILKSL92 HHPNIVGYRA102 FTEANDGSLC112 LAMEYGGEKS122 LNDLIEERYK 132 ASQDPFPAAI142 ILKVALNMAR152 GLKYLHQEKK162 LLHGDIKSSN172 VVIKGDFETI 182 KICDVGVSLP192 LDENMEVTDP202 EACYIGTEPW212 KPKEAVEENG222 VITDKADIFA 232 FGLTLWEMMT242 LSIPHINLSN252 DDDDEDKTFD262 ESDFDDEAYY272 AALGTRPPIN 282 MEELDESYQK292 VIELFSVCTN302 EDPKDRPSAA312 HIVEALETA> Chain B SVLCSTPTIN 28 IPASPFMQKL38 GFGTGVNVYL48 MKRSPRGLSH58 SPWAVKKINP68 ICNDHYRSVY 78 QKRLMDEAKI88 LKSLHHPNIV98 GYRAFTEAND108 GSLCLAMEYG118 GEKSLNDLIE 128 ERYKASQDPF138 PAAIILKVAL148 NMARGLKYLH158 QEKKLLHGDI168 KSSNVVIKGD 178 FETIKICDVG188 VSLPLDENME198 VTDPEACYIG208 TEPWKPKEAV218 EENGVITDKA 228 DIFAFGLTLW238 EMMTLSIPHI248 NLSNDDDDED258 KTFDESDFDD268 EAYYAALGTR 278 PPINMEELDE288 SYQKVIELFS298 VCTNEDPKDR308 PSAAHIVEAL318 EAA |
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|
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TRP61[A]
4.946
LYS65[A]
3.416
ILE66[A]
3.620
ASN67[A]
2.795
PRO68[A]
3.306
TYR78[A]
2.597
ARG101[A]
3.287
PHE103[A]
3.777
ALA114[A]
4.355
MET115[A]
4.261
GLU116[A]
3.164
TYR117[A]
2.812
THR209[A]
3.162
GLU210[A]
3.145
PRO211[A]
4.550
PHE266[A]
4.623
TYR271[A]
4.263
TYR272[A]
3.611
LYS65[B]
3.076
ILE66[B]
3.512
ASN67[B]
2.674
PRO68[B]
3.236
TYR78[B]
3.324
ARG101[B]
3.434
PHE103[B]
3.481
ALA114[B]
4.877
MET115[B]
4.208
GLU116[B]
4.301
TYR117[B]
4.060
THR209[B]
3.435
GLU210[B]
2.920
PRO211[B]
4.683
PHE266[B]
4.161
TYR271[B]
4.214
TYR272[B]
3.435
LYS90[B]
3.125
TYR100[B]
4.087
ARG101[B]
3.363
ALA102[B]
3.077
PHE103[B]
3.816
THR104[B]
3.665
GLU105[B]
3.314
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The crystal structure of an inactive dimer of PDZ-binding kinase. Biochem Biophys Res Commun. 2016 Aug 5;476(4):586-593. | ||||
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