Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T98225 Target Info
Target Name CDC-like kinase 4 (CLK4)
Synonyms Dual specificity protein kinase CLK4
Target Type Literature-reported Target
Gene Name CLK4
Biochemical Class Kinase
UniProt ID
CLK4_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: CX-4945 Ligand Info
Structure Description X-RAY STRUCTURE OF CLK4-KD(146-480)/CX-4945 AT 2.46A PDB:6FYV
Method X-ray diffraction Resolution 2.46 Å Mutation No [1]
PDB Sequence
ICQSGDVLRA
159
RYEIVDTLGE
169
GAFGKVVECI
179
DHGMDGMHVA
189
VKIVKNVGRY
199

REAARSEIQV
209
LEHLNSTDPN
219
SVFRCVQMLE
229
WFDHHGHVCI
239
VFELLGLSTY
249

DFIKENSFLP
259
FQIDHIRQMA
269
YQICQSINFL
279
HHNKLTHTDL
289
KPENILFVKS
299

DYVVKYNKRD
312
ERTLKNTDIK
322
VVDFGSATYD
332
DEHHSTLVST
342
RHYRAPEVIL
352

ALGWSQPCDV
362
WSIGCILIEY
372
YLGFTVFQTH
382
DSKEHLAMME
392
RILGPIPQHM
402

IQKTRKRKYF
412
HHNQLDWDEH
422
SSAGRYVRRR
432
CKPLKEFMLC
442
HDEEHEKLFD
452

LVRRMLEYDP
462
TQRITLDEAL
472
QHPFFDLLK
Residue
Distance (Å)
LEU167
3.480
GLY168
3.482
GLU169
3.477
GLY170
4.344
PHE172
3.368
VAL175
3.756
ALA189
3.512
LYS191
2.788
GLU206
3.794
VAL225
4.140
Residue
Distance (Å)
PHE241
3.415
GLU242
3.697
LEU243
3.834
LEU244
2.868
GLY245
4.196
ASP250
4.510
LEU295
3.650
VAL324
3.629
ASP325
2.920
PHE326
4.454
References  Top
REF 1 X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome. ChemMedChem. 2018 Sep 19;13(18):1997-2007.

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