Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T98157 | Target Info | |||
| Target Name | Cerebroside-sulfatase (ARSA) | ||||
| Synonyms | Cerebrosidesulfatase; Arylsulfatase A component C; ASA; ARSA | ||||
| Target Type | Successful Target | ||||
| Gene Name | ARSA | ||||
| Biochemical Class | Sulfuric ester hydrolase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 4-Nitrocatechol sulfate | Ligand Info | |||||
| Structure Description | Crystal structure of an Arylsulfatase A mutant C69A | PDB:1E2S | ||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | Yes | [1] |
| PDB Sequence |
RPPNIVLIFA
28 DDLGYGDLGC38 YGHPSSTTPN48 LDQLAAGGLR58 FTDFYVPVSL68 ATPSRAALLT 78 GRLPVRMGMY88 PGVLVPSSRG98 GLPLEEVTVA108 EVLAARGYLT118 GMAGKWHLGV 128 GPEGAFLPPH138 QGFHRFLGIP148 YSHDQGPCQN158 LTCFPPATPC168 DGGCDQGLVP 178 IPLLANLSVE188 AQPPWLPGLE198 ARYMAFAHDL208 MADAQRQDRP218 FFLYYASHHT 228 HYPQFSGQSF238 AERSGRGPFG248 DSLMELDAAV258 GTLMTAIGDL268 GLLEETLVIF 278 TADNGPETMR288 MSRGGCSGLL298 RCGKGTTYEG308 GVREPALAFW318 PGHIAPGVTH 328 ELASSLDLLP338 TLAALAGAPL348 PNVTLDGFDL358 SPLLLGTGKS368 PRQSLFFYPS 378 YPDEVRGVFA388 VRTGKYKAHF398 FTQGSAHSDT408 TADPACHASS418 SLTAHEPPLL 428 YDLSKDPGEN438 YNLLGATPEV452 LQALKQLQLL462 KAQLDAAVTF472 GPSQVARGED 482 PALQICCHPG492 CTPRPACCHC502 P
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of an enzyme-substrate complex provides insight into the interaction between human arylsulfatase A and its substrates during catalysis. J Mol Biol. 2001 Jan 12;305(2):269-77. | ||||
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