Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T97917 | Target Info | |||
| Target Name | FMLP-related receptor I (FPR2) | ||||
| Synonyms | RFP; Lipoxin A4 receptor; LXA4 receptor; HM63; G-protein-coupled receptor FPR-Like-1; Formyl peptide receptor-like 1; FPRL1; FPR2; FMLP-R-I | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | FPR2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi | PDB:6OMM | ||||
| Method | Electron microscopy | Resolution | 3.17 Å | Mutation | Yes | [1] |
| PDB Sequence |
GYTVLRILPL
30 VVLGVTFVLG40 VLGNGLVIWV50 AGFRMTRTVT60 TICYLNLALA70 DFSFTATLPF 80 LIVSMAMGEK90 WPFGWFLCKL100 IHIVVDINLF110 GSVFLIGFIA120 LDRCICVLHP 130 VWAQNHRTVS140 LAMKVIVGPW150 ILALVLTLPV160 FLFLTTVTIP170 NGDTYCTFNF 180 ASWGGTPEER190 LKVAITMLTA200 RGIIRFVIGF210 SLPMSIVAIC220 YGLIAAKIHK 230 KGMIKSSRPL240 RVLTAVVASF250 FICWFPFQLV260 ALLGTVWLKE270 MLFYGKYKII 280 DILVNPTSSL290 AFFNSCLNPM300 LYVFVGQDFR310 ERLIHSL
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ILE27
3.731
LEU30
3.740
VAL31
3.971
GLY34
3.633
VAL35
3.638
PHE37
3.780
VAL38
3.756
ILE82
4.210
VAL83
3.830
ALA86
4.023
MET87
4.159
PHE118
3.613
LEU121
3.994
ILE125
3.759
HIS129
3.771
TRP132
3.552
|
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| Ligand Name: Pyrazolone, 1 | Ligand Info | |||||
| Structure Description | Structure of the human FPR2-Gi complex with compound C43 | PDB:7T6S | ||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | No | [2] |
| PDB Sequence |
AGYTVLRILP
29 LVVLGVTFVL39 GVLGNGLVIW49 VAGFRMTRTV59 TTICYLNLAL69 ADFSFTATLP 79 FLIVSMAMGE89 KWPFGWFLCK99 LIHIVVDINL109 FGSVFLIGFI119 ALDRCICVLH 129 PVWAQNHRTV139 SLAMKVIVGP149 WILALVLTLP159 VFLFLTTVTI169 PNGDTYCTFN 179 FASWGGTPEE189 RLKVAITMLT199 ARGIIRFVIG209 FSLPMSIVAI219 CYGLIAAKIH 229 KKGMIKSSRP239 LRVLTAVVAS249 FFICWFPFQL259 VALLGTVWLK269 EMLFYGKYKI 279 IDILVNPTSS289 LAFFNSCLNP299 MLYVFVGQDF309 RERLIHSL
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| Ligand Name: d-Methioninamide | Ligand Info | |||||
| Structure Description | Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi | PDB:6OMM | ||||
| Method | Electron microscopy | Resolution | 3.17 Å | Mutation | Yes | [1] |
| PDB Sequence |
GYTVLRILPL
30 VVLGVTFVLG40 VLGNGLVIWV50 AGFRMTRTVT60 TICYLNLALA70 DFSFTATLPF 80 LIVSMAMGEK90 WPFGWFLCKL100 IHIVVDINLF110 GSVFLIGFIA120 LDRCICVLHP 130 VWAQNHRTVS140 LAMKVIVGPW150 ILALVLTLPV160 FLFLTTVTIP170 NGDTYCTFNF 180 ASWGGTPEER190 LKVAITMLTA200 RGIIRFVIGF210 SLPMSIVAIC220 YGLIAAKIHK 230 KGMIKSSRPL240 RVLTAVVASF250 FICWFPFQLV260 ALLGTVWLKE270 MLFYGKYKII 280 DILVNPTSSL290 AFFNSCLNPM300 LYVFVGQDFR310 ERLIHSL
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of formylpeptide receptor 2-G(i) complex reveals insights into ligand recognition and signaling. Nat Commun. 2020 Feb 14;11(1):885. | ||||
| REF 2 | Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nat Commun. 2022 Feb 25;13(1):1054. | ||||
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