Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T97136 Target Info
Target Name MAPK signal-integrating kinase 1 (MKNK1)
Synonyms Mnk1; MAP kinase signal-integrating kinase 1
Target Type Clinical trial Target
Gene Name MKNK1
Biochemical Class Protein kinase superfamily. CAMK Ser/Thr protein kinase family
UniProt ID
MKNK1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 1-methyl-N-(5-phenyl-1,3-thiazol-2-yl)piperidine-4-carboxamide Ligand Info
Structure Description Structure of Mnk1 in complex with DS12881479 PDB:5WVD
Method X-ray diffraction Resolution 3.00 Å Mutation No [1]
PDB Sequence
PGKFEDMYKL
50
TSELLGEGAY
60
AKVQGAVSLQ
70
NGKEYAVKII
80
EKQAGHSRSR
90

VFREVETLYQ
100
CQGNKNILEL
110
IEFFEDDTRF
120
YLVFEKLQGG
130
SILAHIQKQK
140

HFNEREASRV
150
VRDVAAALDF
160
LHTKGIAHRD
170
LKPENILCES
180
PEKVSPVKIC
190

DFDLGSGYMA
223
PEVVEVFTDQ
233
ATFYDKRCDL
243
WSLGVVLYIM
253
LSGYPPFKYE
293

FPDKDWAHIS
303
SEAKDLISKL
313
LVRDAKQRLS
323
AAQVLQHPWV
333
Q
Residue
Distance (Å)
GLU53
3.459
LEU55
3.573
VAL63
3.720
ALA76
3.672
LYS78
4.300
LEU108
3.706
PHE124
3.577
GLU125
3.495
LYS126
3.699
Residue
Distance (Å)
LEU127
3.030
GLN128
3.429
GLY129
3.446
GLY130
3.823
LEU177
3.659
CYS190
3.798
ASP191
3.342
PHE192
3.620
References  Top
REF 1 A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1. Acta Crystallogr F Struct Biol Commun. 2018 Mar 1;74(Pt 3):156-160.

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