Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T96837 | Target Info | |||
| Target Name | Immunoglobulin gamma-1 heavy NIE (NIE) | ||||
| Synonyms | Immunoglobulin gamma-1 heavy chain NIE | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NIE | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: L-ornithine | Ligand Info | |||||
| Structure Description | Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope | PDB:1N0X | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [1] |
| PDB Sequence |
QVQLVQSGAE
10 VKKPGASVKV20 SCQASGYRFS30 NFVIHWVRQA40 PGQRFEWMGW50 INPYNGNKEF 59 SAKFQDRVTF69 TADTSANTAY79 MELRSLRSAD86 TAVYYCARVG96 PYSWDDSPQD 100F NYYMDVWGKG106 TTVIVSSAST116 KGPSVFPLAP126 SSTAALGCLV144 KDYFPEPVTV 154 SWNSGALTSG169 VHTFPAVLQS180 SGLYSLSSVV191 TVPSSSLGTQ203 TYICNVNHKP 214 SNTKVDKKVE226 PK
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| Ligand Name: Glutarate | Ligand Info | |||||
| Structure Description | X-ray crystal structure of covalent-bonded complex of Fc and peptide | PDB:6IQH | ||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | No | [2] |
| PDB Sequence |
GPSVFLFPPK
246 PKDTLMISRT256 PEVTCVVVDV266 SHEDPEVKFN276 WYVDGVEVHN286 AKTKPREEQY 296 NSTYRVVSVL306 TVLHQDWLNG316 KEYKCKVSNK326 ALPAPIEKTI336 SKAKGQPREP 346 QVYTLPPSRD356 ELTKNQVSLT366 CLVKGFYPSD376 IAVEWESNGQ386 PENNYKTTPP 396 VLDSDGSFFL406 YSKLTVDKSR416 WQQGNVFSCS426 VMHEALHNHY436 TQKSLSL |
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| Ligand Name: 3-Cyclohexyl-1-propylsulfonic acid | Ligand Info | |||||
| Structure Description | Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope | PDB:1N0X | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [1] |
| PDB Sequence |
QVQLVQSGAE
10 VKKPGASVKV20 SCQASGYRFS30 NFVIHWVRQA40 PGQRFEWMGW50 INPYNGNKEF 59 SAKFQDRVTF69 TADTSANTAY79 MELRSLRSAD86 TAVYYCARVG96 PYSWDDSPQD 100F NYYMDVWGKG106 TTVIVSSAST116 KGPSVFPLAP126 SSTAALGCLV144 KDYFPEPVTV 154 SWNSGALTSG169 VHTFPAVLQS180 SGLYSLSSVV191 TVPSSSLGTQ203 TYICNVNHKP 214 SNTKVDKKVE226 PK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CXS or .CXS2 or .CXS3 or :3CXS;style chemicals stick;color identity;select .H:98 or .H:99 or .H:100 or .H:100B or .H:100A or .H:100C or .H:100D; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope | ||||
| REF 2 | Site-Specific Chemical Conjugation of Antibodies by Using Affinity Peptide for the Development of Therapeutic Antibody Format. Bioconjug Chem. 2019 Mar 20;30(3):698-702. | ||||
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