Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T96723 Target Info
Target Name SF3b complex (SF3b)
Target Type Clinical trial Target
Gene Name SF3B1-SF3B2-SF3B3-SF3B4-SF3B5-SF3B6
UniProt ID
SF3B1_HUMAN - SF3B2_HUMAN - SF3B3_HUMAN - SF3B4_HUMAN - SF3B5_HUMAN - SF3B6_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Adenine Ligand Info
Structure Description Branch Recognition by SF3b14 PDB:3LQV
Method X-ray diffraction Resolution 2.38 Å Mutation No [1]
PDB Sequence
LPPEVNRILY
22
IRNLPYKITA
32
EEMYDIFGKY
42
GPIRQIRVGN
52
TPETRGTAYV
62

VYEDIFDAKN
72
AVDHLSGFNV
82
SNRYLVVLYY
92
NANRAFQKMD
102
TKKKEEQLKL
112

LKEKYGINTD
122
PPK
Residue
Distance (Å)
TYR22
3.428
TYR61
2.752
LEU90
4.332
TYR91
3.117
TYR92
3.554
Residue
Distance (Å)
ASN93
3.076
ARG96
3.057
ALA97
3.016
GLN99
3.655
References  Top
REF 1 Structural model of the p14/SF3b155 branch duplex complex. RNA. 2011 Jan;17(1):155-65.

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