Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T95761 | Target Info | |||
Target Name | Cell surface antigen MS2 (ADAM8) | ||||
Synonyms | CD156a antigen; CD156; ADAM8; A disintegrin and metalloproteinase domain 8 | ||||
Target Type | Literature-reported Target | ||||
Gene Name | ADAM8 | ||||
Biochemical Class | Peptidase | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: Batimastat | Ligand Info | |||||
Structure Description | ADAM-8 metalloproteinase domain with bound batimastat | PDB:4DD8 | ||||
Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
PDB Sequence |
RETRYVELYV
206 VVDNAEFQML216 GSEAAVRHRV226 LEVVNHVDKL236 YQKLNFRVVL246 VGLEIWNSQD 256 RFHVSPDPSV266 TLENLLTWQA276 RRHLHDNVQL290 ITGVDFTGTT300 VGFARVSAMC 310 SHSSGAVNQD320 HSKNPVGVAC330 TMAHEMGHNL340 GMDHDENVQG350 CRCQERFEAG 360 RCIMAGSIGS370 SFPRMFSDCS380 QAYLESFLER390 PQSVCLANAP400 D |
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References | Top | ||||
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REF 1 | Structure of human ADAM-8 catalytic domain complexed with batimastat. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):616-21. |
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