Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95616 | Target Info | |||
| Target Name | Integrin alpha-M (ITGAM) | ||||
| Synonyms | Neutrophil adherence receptor; Leukocyte adhesion receptor MO1; Cell surface glycoprotein Mac-1; Cell surface glycoprotein MAC-1 subunit alpha; Cell surface glycoprotein MAC-1 alpha subunit; CR3A; CR-3 alpha chain; CD11b; CD11 antigen-like family member B | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | ITGAM | ||||
| Biochemical Class | Integrin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Simvastatin acid | Ligand Info | |||||
| Structure Description | Structural basis for simvastatin competitive antagonism of complement receptor 3 | PDB:4XW2 | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
DSDIAFLIDG
141 SGSIIPHDFR151 RMKEFVSTVM161 EQLKKSKTLF171 SLMQYSEEFR181 IHFTFKEFQN 191 NPNPRSLVKP201 ITQLLGRTHT211 ATGIRKVVRE221 LFNITNGARK231 NAFKILVVIT 241 DGEKFGDPLG251 YEDVIPEADR261 EGVIRYVIGV271 GDAFRSEKSR281 QELNTIASKP 291 PRDHVFQVNN301 FEALKTIQNQ311 LREK
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3. J Biol Chem. 2016 Aug 12;291(33):16963-76. | ||||
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