Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T95553 Target Info
Target Name ADP-ribosylation factor-like protein 2 (ARL2)
Synonyms ARFL2
Target Type Literature-reported Target
Gene Name ARL2
Biochemical Class Small GTPase
UniProt ID
ARL2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Guanosine-5'-Triphosphate Ligand Info
Structure Description Complex of ARL2 and BART, Crystal Form 1 PDB:3DOE
Method X-ray diffraction Resolution 2.25 Å Mutation No [1]
PDB Sequence
GLLTILKKMK
11
QKERELRLLM
21
LGLDNAGKTT
31
ILKKFNGEDI
41
DTISPTLGFN
51

IKTLEHRGFK
61
LNIWDVGGQK
71
SLRSYWRNYF
81
ESTDGLIWVV
91
DSADRQRMQD
101

CQRELQSLLV
111
EERLAGATLL
121
IFANKQDLPG
131
ALSSNAIREV
141
LELDSIRSHH
151

WCIQGCSAVT
161
GENLLPGIDW
171
LLDDISSRIF
181
TADLEHHHH
Residue
Distance (Å)
GLY23
4.815
LEU24
3.626
ASP25
3.475
ASN26
3.142
ALA27
3.216
GLY28
2.766
LYS29
2.630
THR30
2.925
THR31
2.715
ILE44
3.535
SER45
4.399
PRO46
3.514
THR47
2.579
Residue
Distance (Å)
ASP66
4.479
VAL67
4.475
GLY68
3.800
GLY69
2.971
GLN70
4.341
ASN125
3.104
LYS126
3.258
ASP128
2.661
LEU129
3.700
CYS157
4.898
SER158
3.487
ALA159
3.092
VAL160
3.371
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References  Top
REF 1 Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector. Structure. 2009 Apr 15;17(4):602-10.

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