Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T95238 Target Info
Target Name Protein enabled homolog MENA (ENAH)
Synonyms MENA
Target Type Literature-reported Target
Gene Name ENAH
UniProt ID
ENAH_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: (3S,7R,10R,13S)-4-[(3S,6R,8aS)-1'-[(2S)-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxospiro[1,2,3,8a-tetrahydroindolizine-6,2'-pyrrolidine]-3-carbonyl]-2-oxo-1,4-diazatricyclo[8.3.0.03,7]tridec-8-ene-13-carboxylic acid Ligand Info
Structure Description ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-1]-TEDEL-NH2 PDB:6RD2
Method X-ray diffraction Resolution 1.00 Å Mutation No [1]
PDB Sequence
EQSICQARAA
12
VMVYDDANKK
22
WVPAGGSTGF
32
SRVHIYHHTG
42
NNTFRVVGRK
52

IQDHQVVINC
62
AIPKGLKYNQ
72
ATQTFHQWRD
82
ARQVYGLNFG
92
SKEDANVFAS
102

AMMHALEVL
Residue
Distance (Å)
MET14
3.165
TYR16
2.748
TRP23
1.891
LYS69
2.165
TYR70
4.903
ASN71
3.104
ALA73
3.017
Residue
Distance (Å)
THR74
2.617
PHE77
2.634
GLN79
2.091
TRP80
2.446
ARG81
2.304
VAL86
2.342
ASN90
2.780
Ligand Name: (S)-2-Amino-4-methylpentanamide Ligand Info
Structure Description ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-1]-TEDEL-NH2 PDB:6RD2
Method X-ray diffraction Resolution 1.00 Å Mutation No [1]
PDB Sequence
EQSICQARAA
12
VMVYDDANKK
22
WVPAGGSTGF
32
SRVHIYHHTG
42
NNTFRVVGRK
52

IQDHQVVINC
62
AIPKGLKYNQ
72
ATQTFHQWRD
82
ARQVYGLNFG
92
SKEDANVFAS
102

AMMHALEVL
Residue
Distance (Å)
ALA12
3.502
MET14
2.581
PRO25
4.856
THR30
2.381
Residue
Distance (Å)
GLY31
4.613
PHE77
4.965
ASN90
2.906
Ligand Name: (3~{S},7~{R},10~{R},11~{R},13~{S})-4-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-11-methyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid Ligand Info
Structure Description ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-9]-OH PDB:5NCG
Method X-ray diffraction Resolution 1.02 Å Mutation No [1]
PDB Sequence
GSMSEQSICQ
8
ARAAVMVYDD
18
ANKKWVPAGG
28
STGFSRVHIY
38
HHTGNNTFRV
48

VGRKIQDHQV
58
VINCAIPKGL
68
KYNQATQTFH
78
QWRDARQVYG
88
LNFGSKEDAN
98

VFASAMMHAL
108
EVL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .8TB or .8TB2 or .8TB3 or :38TB;style chemicals stick;color identity;select .A:0 or .A:1 or .A:3 or .A:4 or .A:5 or .A:14 or .A:15 or .A:16 or .A:23 or .A:26 or .A:27 or .A:28 or .A:36 or .A:38 or .A:47 or .A:49 or .A:51 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:62 or .A:69 or .A:70 or .A:71 or .A:73 or .A:74 or .A:77 or .A:79 or .A:80 or .A:81 or .A:82 or .A:84 or .A:85 or .A:86 or .A:87 or .A:90; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
SER0
2.365
MET1
2.626
GLU3
2.322
GLN4
2.323
SER5
2.965
MET14
2.449
VAL15
3.892
TYR16
2.763
TRP23
1.914
ALA26
3.534
GLY27
3.015
GLY28
4.019
HIS36
3.216
TYR38
2.448
ARG47
1.976
VAL49
2.165
ARG51
2.458
GLN57
2.860
VAL58
2.427
Residue
Distance (Å)
VAL59
2.819
ILE60
2.500
ASN61
2.426
CYS62
4.660
LYS69
2.493
TYR70
4.498
ASN71
2.721
ALA73
2.631
THR74
2.628
PHE77
2.928
GLN79
2.098
TRP80
2.487
ARG81
2.193
ASP82
4.383
ARG84
2.491
GLN85
2.379
VAL86
2.469
TYR87
2.067
ASN90
3.586
Ligand Name: 2-[(3~{a}~{R},6~{R},8~{a}~{S})-1-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-6-ethyl-8-oxidanylidene-3,3~{a},6,8~{a}-tetrahydro-2~{H}-pyrrolo[2,3-c]azepin-7-yl]ethanoic acid Ligand Info
Structure Description ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-15]-OH PDB:6RCF
Method X-ray diffraction Resolution 1.10 Å Mutation No [1]
PDB Sequence
MSEQSICQAR
10
AAVMVYDDAN
20
KKWVPAGGST
30
GFSRVHIYHH
40
TGNNTFRVVG
50

RKIQDHQVVI
60
NCAIPKGLKY
70
NQATQTFHQW
80
RDARQVYGLN
90
FGSKEDANVF
100

ASAMMHALEV
110
L
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K0K or .K0K2 or .K0K3 or :3K0K;style chemicals stick;color identity;select .A:14 or .A:16 or .A:21 or .A:22 or .A:23 or .A:69 or .A:70 or .A:71 or .A:73 or .A:74 or .A:77 or .A:79 or .A:80 or .A:81 or .A:86 or .A:90; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
MET14
2.580
TYR16
2.853
LYS21
4.958
LYS22
4.971
TRP23
1.984
LYS69
2.000
TYR70
4.744
ASN71
3.082
Residue
Distance (Å)
ALA73
3.143
THR74
2.374
PHE77
2.305
GLN79
1.956
TRP80
2.560
ARG81
0.637
VAL86
2.623
ASN90
2.830
Ligand Name: (3~{s},6~{s},7~{r},9~{a}~{r})-6-[[(3~{s},6~{r},8~{a}~{s})-1'-[(2~{s})-2-Acetamido-3-(2-Chlorophenyl)propanoyl]-5-Oxidanylidene-Spiro[1,2,3,8~{a}-Tetrahydroindolizine-6,2'-Pyrrolidine]-3-Yl]carbonylamino]-7-Methyl-5-Oxidanylidene-1,2,3,6,7,9~{a}-Hexahydropyrrolo[1,2-A]azepine-3-Carboxylic Acid Ligand Info
Structure Description ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-3]-OH PDB:5NBF
Method X-ray diffraction Resolution 1.15 Å Mutation No [1]
PDB Sequence
SEQSICQARA
11
AVMVYDDANK
21
KWVPAGGSTG
31
FSRVHIYHHT
41
GNNTFRVVGR
51

KIQDHQVVIN
61
CAIPKGLKYN
71
QATQTFHQWR
81
DARQVYGLNF
91
GSKEDANVFA
101

SAMMHALEVL
111
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .8S8 or .8S82 or .8S83 or :38S8;style chemicals stick;color identity;select .A:14 or .A:16 or .A:21 or .A:23 or .A:69 or .A:70 or .A:71 or .A:73 or .A:74 or .A:77 or .A:79 or .A:80 or .A:81 or .A:86 or .A:90; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
MET14
2.950
TYR16
2.707
LYS21
4.871
TRP23
1.910
LYS69
2.152
TYR70
4.743
ASN71
2.946
ALA73
3.083
Residue
Distance (Å)
THR74
2.341
PHE77
2.401
GLN79
2.200
TRP80
2.568
ARG81
1.957
VAL86
2.527
ASN90
2.936
Ligand Name: ethyl (3~{S},7~{R},10~{R},11~{R},13~{S})-4-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-11-ethyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylate Ligand Info
Structure Description ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-13]-OEt PDB:5NEG
Method X-ray diffraction Resolution 1.29 Å Mutation No [1]
PDB Sequence
EQSICQARAA
12
VMVYDDANKK
22
WVPAGGSTGF
32
SRVHIYHHTG
42
NNTFRVVGRK
52

IQDHQVVINC
62
AIPKGLKYNQ
72
ATQTFHQWRD
82
ARQVYGLNFG
92
SKEDANVFAS
102

AMMHALEVL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .8VK or .8VK2 or .8VK3 or :38VK;style chemicals stick;color identity;select .A:12 or .A:14 or .A:16 or .A:18 or .A:23 or .A:69 or .A:70 or .A:71 or .A:73 or .A:74 or .A:77 or .A:79 or .A:80 or .A:81 or .A:86 or .A:90; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ALA12
4.954
MET14
2.684
TYR16
2.809
ASP18
4.709
TRP23
1.976
LYS69
2.068
TYR70
4.659
ASN71
2.953
Residue
Distance (Å)
ALA73
3.087
THR74
2.742
PHE77
2.329
GLN79
2.120
TRP80
2.488
ARG81
1.925
VAL86
2.142
ASN90
2.725
Ligand Name: methyl 2-[(3~{a}~{R},6~{R},8~{a}~{S})-1-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-6-ethyl-8-oxidanylidene-3,3~{a},6,8~{a}-tetrahydro-2~{H}-pyrrolo[2,3-c]azepin-7-yl]ethanoate Ligand Info
Structure Description ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-15]-OMe PDB:6RCJ
Method X-ray diffraction Resolution 1.35 Å Mutation No [1]
PDB Sequence
SEQSICQARA
11
AVMVYDDANK
21
KWVPAGGSTG
31
FSRVHIYHHT
41
GNNTFRVVGR
51

KIQDHQVVIN
61
CAIPKGLKYN
71
QATQTFHQWR
81
DARQVYGLNF
91
GSKEDANVFA
101

SAMMHALEVL
111
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K0H or .K0H2 or .K0H3 or :3K0H;style chemicals stick;color identity;select .A:14 or .A:16 or .A:18 or .A:22 or .A:23 or .A:69 or .A:70 or .A:71 or .A:73 or .A:74 or .A:77 or .A:79 or .A:80 or .A:81 or .A:86 or .A:90; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
MET14
2.724
TYR16
2.818
ASP18
4.856
LYS22
4.265
TRP23
1.907
LYS69
1.860
TYR70
4.797
ASN71
3.010
Residue
Distance (Å)
ALA73
3.162
THR74
2.423
PHE77
2.216
GLN79
2.041
TRP80
2.499
ARG81
1.906
VAL86
2.572
ASN90
2.645
Ligand Name: (3~{S},7~{R},10~{R},13~{S})-4-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxamide Ligand Info
Structure Description ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-1]-NH2 PDB:7AKI
Method X-ray diffraction Resolution 1.36 Å Mutation No [1]
PDB Sequence
GSMSEQSICQ
8
ARAAVMVYDD
18
ANKKWVPAGG
28
STGFSRVHIY
38
HHTGNNTFRV
48

VGRKIQDHQV
58
VINCAIPKGL
68
KYNQATQTFH
78
QWRDARQVYG
88
LNFGSKEDAN
98

VFASAMMHAL
108
EVL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .RJQ or .RJQ2 or .RJQ3 or :3RJQ;style chemicals stick;color identity;select .A:-1 or .A:0 or .A:1 or .A:3 or .A:4 or .A:5 or .A:14 or .A:16 or .A:22 or .A:23 or .A:36 or .A:38 or .A:47 or .A:49 or .A:51 or .A:58 or .A:61 or .A:69 or .A:70 or .A:71 or .A:73 or .A:74 or .A:77 or .A:79 or .A:80 or .A:81 or .A:86 or .A:90; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLY-1
2.575
SER0
2.909
MET1
3.084
GLU3
2.079
GLN4
2.177
SER5
2.999
MET14
3.749
TYR16
2.796
LYS22
1.826
TRP23
1.999
HIS36
3.034
TYR38
1.657
ARG47
1.984
VAL49
2.372
Residue
Distance (Å)
ARG51
2.402
VAL58
2.383
ASN61
1.738
LYS69
2.493
TYR70
4.296
ASN71
2.745
ALA73
2.529
THR74
2.595
PHE77
2.985
GLN79
2.682
TRP80
2.446
ARG81
2.050
VAL86
2.198
ASN90
4.531
Ligand Name: (1~{s},4~{s},7~{r},10~{r})-14-[(3~{s},6~{r},8~{a}~{s})-1'-[(2~{s})-2-Acetamido-3-(2-Chlorophenyl)propanoyl]-5-Oxidanylidene-Spiro[1,2,3,8~{a}-Tetrahydroindolizine-6,2'-Pyrrolidine]-3-Yl]carbonyl-2-Oxidanylidene-3,14-Diazatricyclo[8.4.0.0^{3,7}]tetradec-8-Ene-4-Carboxylic Acid Ligand Info
Structure Description ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-4]-OH PDB:5NCF
Method X-ray diffraction Resolution 1.40 Å Mutation No [1]
PDB Sequence
GSMSEQSICQ
8
ARAAVMVYDD
18
ANKKWVPAGG
28
STGFSRVHIY
38
HHTGNNTFRV
48

VGRKIQDHQV
58
VINCAIPKGL
68
KYNQATQTFH
78
QWRDARQVYG
88
LNFGSKEDAN
98

VFASAMMHAL
108
EVL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .8T5 or .8T52 or .8T53 or :38T5;style chemicals stick;color identity;select .A:14 or .A:16 or .A:23 or .A:69 or .A:70 or .A:71 or .A:73 or .A:74 or .A:77 or .A:79 or .A:80 or .A:81 or .A:86 or .A:90; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
MET14
2.326
TYR16
2.822
TRP23
1.858
LYS69
2.438
TYR70
4.662
ASN71
3.014
ALA73
2.867
Residue
Distance (Å)
THR74
2.811
PHE77
2.467
GLN79
2.333
TRP80
2.507
ARG81
2.047
VAL86
2.306
ASN90
3.626
Ligand Name: 7}]Tridec-8-ene-13-carboxylate Ligand Info
Structure Description ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-12]-OMe PDB:5NDU
Method X-ray diffraction Resolution 1.42 Å Mutation No [1]
PDB Sequence
EQSICQARAA
12
VMVYDDANKK
22
WVPAGGSTGF
32
SRVHIYHHTG
42
NNTFRVVGRK
52

IQDHQVVINC
62
AIPKGLKYNQ
72
ATQTFHQWRD
82
ARQVYGLNFG
92
SKEDANVFAS
102

AMMHALEVL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .8V2 or .8V22 or .8V23 or :38V2;style chemicals stick;color identity;select .A:14 or .A:16 or .A:22 or .A:23 or .A:69 or .A:70 or .A:71 or .A:73 or .A:74 or .A:77 or .A:79 or .A:80 or .A:81 or .A:86 or .A:90; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
MET14
4.585
TYR16
2.695
LYS22
4.544
TRP23
1.999
LYS69
2.229
TYR70
4.652
ASN71
2.923
ALA73
3.123
Residue
Distance (Å)
THR74
2.373
PHE77
2.432
GLN79
1.909
TRP80
2.502
ARG81
1.722
VAL86
2.309
ASN90
3.323
Ligand Name: (3~{s},7~{r},10~{r},13~{s})-4-[[(3~{s},7~{r},10~{r},13~{s})-4-[(2~{s})-2-Acetamido-3-(2-Chlorophenyl)propanoyl]-2-Oxidanylidene-1,4-Diazatricyclo[8.3.0.0^{3,7}]tridec-8-En-13-Yl]carbonyl]-2-Oxidanylidene-1,4-Diazatricyclo[8.3.0.0^{3,7}]tridec-8-Ene-13-Carboxylic Acid Ligand Info
Structure Description ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-1]-[ProM-1]-OH PDB:5NAJ
Method X-ray diffraction Resolution 1.46 Å Mutation No [1]
PDB Sequence
SEQSICQARA
11
AVMVYDDANK
21
KWVPAGGSTG
31
FSRVHIYHHT
41
GNNTFRVVGR
51

KIQDHQVVIN
61
CAIPKGLKYN
71
QATQTFHQWR
81
DARQVYGLNF
91
GSKEDANVFA
101

SAMMHALEVL
111
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .8SE or .8SE2 or .8SE3 or :38SE;style chemicals stick;color identity;select .A:14 or .A:16 or .A:23 or .A:69 or .A:70 or .A:71 or .A:73 or .A:74 or .A:77 or .A:79 or .A:80 or .A:81 or .A:86 or .A:90; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
MET14
2.704
TYR16
2.681
TRP23
2.050
LYS69
2.613
TYR70
4.558
ASN71
2.890
ALA73
2.823
Residue
Distance (Å)
THR74
2.720
PHE77
2.431
GLN79
2.203
TRP80
2.639
ARG81
2.297
VAL86
2.564
ASN90
2.807
Ligand Name: (3~{S},7~{R},10~{R},13~{R})-4-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid Ligand Info
Structure Description ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-12]-OH PDB:5NCP
Method X-ray diffraction Resolution 1.65 Å Mutation No [1]
PDB Sequence
EQSICQARAA
12
VMVYDDANKK
22
WVPAGGSTGF
32
SRVHIYHHTG
42
NNTFRVVGRK
52

IQDHQVVINC
62
AIPKGLKYNQ
72
ATQTFHQWRD
82
ARQVYGLNFG
92
SKEDANVFAS
102

AMMHALEVL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .EG5 or .EG52 or .EG53 or :3EG5;style chemicals stick;color identity;select .A:14 or .A:16 or .A:23 or .A:69 or .A:70 or .A:71 or .A:73 or .A:74 or .A:77 or .A:79 or .A:80 or .A:81 or .A:86 or .A:90; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
MET14
4.192
TYR16
2.711
TRP23
1.955
LYS69
2.205
TYR70
4.752
ASN71
2.959
ALA73
3.177
Residue
Distance (Å)
THR74
2.390
PHE77
2.354
GLN79
1.905
TRP80
2.531
ARG81
2.164
VAL86
2.228
ASN90
3.018
Ligand Name: (3aR,5aS,8S,10aS)-1-({(3S,6R,8aS)-1'-[(2S)-2-(acetylamino)-3-(2-chlorophenyl)propanoyl]-5-oxo-1,2,3,8a-tetrahydrospiro[indolizine-6,2'-pyrrolidin]-3-yl}carbonyl)-10-oxo-1,2,3,3a,5a,8,10,10a-octahydrodipyrrolo[1,2-a:3',2'-e]azepine-8-carboxylic acid (non-preferred name) Ligand Info
Structure Description EnaH-EVH1 in complex with peptidomimetic low-molecular weight inhibitor Ac-[2-Cl-F]-[ProM-2]-[ProM-1]-OH PDB:4MY6
Method X-ray diffraction Resolution 1.70 Å Mutation No [2]
PDB Sequence
SEQSICQARA
11
AVMVYDDANK
21
KWVPAGGSTG
31
FSRVHIYHHT
41
GNNTFRVVGR
51

KIQDHQVVIN
61
CAIPKGLKYN
71
QATQTFHQWR
81
DARQVYGLNF
91
GSKEDANVFA
101

SAMMHALEVL
111
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .3VH or .3VH2 or .3VH3 or :33VH;style chemicals stick;color identity;select .A:14 or .A:16 or .A:23 or .A:69 or .A:70 or .A:71 or .A:73 or .A:74 or .A:77 or .A:79 or .A:80 or .A:81 or .A:86 or .A:90; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
MET14
4.105
TYR16
3.522
TRP23
2.799
LYS69
3.461
TYR70
4.892
ASN71
3.667
ALA73
4.138
Residue
Distance (Å)
THR74
4.014
PHE77
3.465
GLN79
3.082
TRP80
3.803
ARG81
2.907
VAL86
3.497
ASN90
4.129
References  Top
REF 1 Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29684-29690.
REF 2 A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5011-6.

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