Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95183 | Target Info | |||
| Target Name | Ubiquitin carboxyl-terminal hydrolase 2 (USP2) | ||||
| Synonyms | Ubiquitin-specific-processing protease 2; Ubiquitin thioesterase 2; UBP41; Deubiquitinating enzyme 2; 41 kDa ubiquitin-specific protease | ||||
| Target Type | Preclinical Target | ||||
| Gene Name | USP2 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Thioguanine | Ligand Info | |||||
| Structure Description | Crystal structure of human USP2 in complex with ubiquitin and 6-thioguanine | PDB:5XU8 | ||||
| Method | X-ray diffraction | Resolution | 1.81 Å | Mutation | No | [1] |
| PDB Sequence |
QGLAGLRNLG
273 NTCFMNSILQ283 CLSNTRELRD293 YCLQRLYMRD303 LHHGSNAHTA313 LVEEFAKLIQ 323 TIWTSSPNDV333 VSPSEFKTQI343 QRYAPRFVGY353 NQQDAQEFLR363 FLLDGLHNEV 373 NRVNLDHLPD392 DEKGRQMWRK402 YLEREDSRIG412 DLFVGQLKSS422 LTCTDCGYCS 432 TVFDPFWDLS442 LPIAKRGYPE452 VTLMDCMRLF462 TKEDVLDGDE472 KPTCCRCRGR 482 KRCIKKFSIQ492 RFPKILVLHL502 KRFSESRIRT512 SKLTTFVNFP522 LRDLDLREFA 532 SENTNHAVYN542 LYAVSNHSGT552 TMGGHYTAYC562 RSPGTGEWHT572 FNDSSVTPMS 582 SSQVRTSDAY592 LLFYELA
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| Ligand Name: Ethylamine | Ligand Info | |||||
| Structure Description | Covalent Ubiquitin-USP2 Complex | PDB:2IBI | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | Yes | [2] |
| PDB Sequence |
AQGLAGLRNL
272 GNTCFMNSIL282 QCLSNTRELR292 DYCLQRLYMR302 DLHHGSNAHT312 ALVEEFAKLI 322 QTIWTSSPND332 VVSPSEFKTQ342 IQRYAPRFVG352 YNQQDAQEFL362 RFLLDGLHNE 372 VNRVTLRPKN383 PENLDHLPDD393 EKGRQMWRKY403 LEREDSRIGD413 LFVGQLKSSL 423 TCTDCGYCST433 VFDPFWDLSL443 PIAKRGPEVT454 LMDCMRLFTK464 EDVLDGDAAP 474 TCCRCRGRKR484 CIKKFSIQRF494 PKILVLHLKR504 FSESRIRTSK514 LTTFVNFPLR 524 DLDLREFASE534 NTHAVYNLYA545 VSNHSGTTMG555 GHYTAYCRSP565 GTGEWHTFND 575 SSVTPMSSSQ585 VRTSDAYLLF595 YELAS
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. Sci Rep. 2018 Feb 15;8(1):3102. | ||||
| REF 2 | Covalent Ubiquitin-USP2 Complex | ||||
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