Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T95033 Target Info
Target Name Oxidoreductase HTATIP2 (HTATIP2)
Synonyms HIV-1 TAT-interactive protein 2; 30 kDa HIV-1 TAT-interacting protein
Target Type Literature-reported Target
Gene Name HTATIP2
UniProt ID
HTAI2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: NADPH Ligand Info
Structure Description CC3(TIP30)Crystal Structure PDB:2BKA
Method X-ray diffraction Resolution 1.70 Å Mutation No [1]
PDB Sequence
EALSKLREDF
14
RMQNKSVFIL
24
GASGETGRVL
34
LKEILEQGLF
44
SKVTLIGRRK
54

LTFDEEAYKN
64
VNQEVVDFEK
74
LDDYASAFQG
84
HDVGFCCLGT
94
TRGKAGAEGF
104

VRVDRDYVLK
114
SAELAKAGGC
124
KHFNLLSSKG
134
ADKSSNFLYL
144
QVKGEVEAKV
154

EELKFDRYSV
164
FRPGVLLCDR
174
QESRPGEWLV
184
RKFFGSLPDS
194
WASGHSVPVV
204

TVVRAMLNNV
214
VRPRDKQMEL
224
LENKAIHDLG
234
KA
Residue
Distance (Å)
GLY25
3.172
ALA26
4.264
SER27
2.621
GLY28
3.128
GLU29
2.823
THR30
2.899
GLY31
4.637
ARG52
2.784
ARG53
2.881
PHE72
3.789
CYS91
3.346
LEU92
2.733
GLY93
3.109
THR94
3.800
Residue
Distance (Å)
LYS98
4.005
VAL107
3.362
ASP108
4.092
TYR111
3.854
LEU130
3.235
SER131
3.126
SER132
3.853
TYR143
2.677
LYS147
2.789
PRO167
3.610
GLY168
3.618
VAL169
3.723
LEU170
2.900
References  Top
REF 1 Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor. J Biol Chem. 2005 May 6;280(18):18229-36.

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