Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T94823 Target Info
Target Name Xaa-Pro dipeptidase (PEPD)
Synonyms X-Pro dipeptidase; Proline dipeptidase; Prolidase; PEPD; Imidodipeptidase
Target Type Literature-reported Target
Gene Name PEPD
Biochemical Class Peptidase
UniProt ID
PEPD_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: L-leucine Ligand Info
Structure Description Crystal Structure of Wild-Type Human Prolidase with Mg ions and LeuPro ligand PDB:5M4L
Method X-ray diffraction Resolution 1.49 Å Mutation No [1]
PDB Sequence
GPSFWLGNET
15
LKVPLALFAL
25
NRQRLCERLR
35
KNPAVQAGSI
45
VVLQGGEETQ
55

RYCTDTGVLF
65
RQESFFHWAF
75
GVTEPGCYGV
85
IDVDTGKSTL
95
FVPRLPASHA
105

TWMGKIHSKE
115
HFKEKYAVDD
125
VQYVDEIASV
135
LTSQKPSVLL
145
TLRGVNTDSG
155

SVCREASFDG
165
ISKFEVNNTI
175
LHPEIVECRV
185
FKTDMELEVL
195
RYTNKISSEA
205

HREVMKAVKV
215
GMKEYELESL
225
FEHYCYSRGG
235
MRHSSYTCIC
245
GSGENSAVLH
255

YGHAGAPNDR
265
TIQNGDMCLF
275
DMGGEYYCFA
285
SDITCSFPAN
295
GKFTADQKAV
305

YEAVLRSSRA
315
VMGAMKPGVW
325
WPDMHRLADR
335
IHLEELAHMG
345
ILSGSVDAMV
355

QAHLGAVFMP
365
HGLGHFLGID
375
VHDVGGYPEG
385
VERIDEPGLR
395
SLRTARHLQP
405

GMVLTVEPGI
415
YFIDHLLDEA
425
LADPARASFL
435
NREVLQRFRG
445
FGGVRIEEDV
455

VVTDSGIELL
465
TCVPRTVEEI
475
EACMAGCDKA
485
FTPF
Residue
Distance (Å)
TYR241
3.642
ILE244
3.458
LEU254
4.998
HIS255
3.672
ASP276
3.139
ASP287
2.991
Residue
Distance (Å)
HIS370
3.354
VAL376
3.830
HIS377
2.769
GLU412
4.025
ARG450
4.796
GLU452
4.368
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 Substrate specificity and reaction mechanism of human prolidase. FEBS J. 2017 Sep;284(17):2870-2885.

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