Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T94366 Target Info
Target Name Hsp90 co-chaperone Cdc37 (CDC37)
Synonyms p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; Hsp90 chaperone protein kinase-targeting subunit; CDC37A
Target Type Literature-reported Target
Gene Name CDC37
UniProt ID
CDC37_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: L-serine-O-phosphate Ligand Info
Structure Description Structure of the RAF1-HSP90-CDC37 complex (RHC-I) PDB:7Z38
Method Electron microscopy Resolution 3.16 Å Mutation No [1]
PDB Sequence
VDYSVWDHIE
11
VDDEDETHPN
22
IDTASLFRWR
32
HQARVERMEQ
42
FQKEKEELDR
52

GCRECKRKVA
62
ECQRKLKELE
72
VAEGGKAELE
82
RLQAEAQQLR
92
KEERSWEQKL
102

EEMRKKEKSM
112
PWNVDTLSKD
122
GFSKSMVNTK
132
PEKTEEDSEE
142
VREQKHKTFV
152

EKYEKQIKHF
162
GMLRRWDDSQ
172
KYLSDNVHLV
182
CEETANYLVI
192
WCIDLEVEEK
202

CALMEQVAHQ
212
TIVMQFILEL
222
AKSLKVDPRA
232
CFRQFFTKIK
242
TADRQYMEGF
252

NDELEAFKER
262
VRGRAKLRIE
272
KA
Residue
Distance (Å)
GLU11
3.668
VAL12
1.331
ASP14
1.327
ASP15
2.778
PHE29
4.086
Residue
Distance (Å)
ARG32
2.737
HIS33
2.610
ARG36
2.697
ASN115
4.672
VAL116
3.985
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation. Mol Cell. 2022 Sep 15;82(18):3438-3452.e8.

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