Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93283 | Target Info | |||
| Target Name | Prostatic acid phosphatase (ACPP) | ||||
| Synonyms | Thiamine monophosphatase; TMPase; PAP | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | ACPP | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: alpha-Benzyl-aminobenzyl-phosphonic acid | Ligand Info | |||||
| Structure Description | Crystal Structures of Human Prostatic Acid Phosphatase in Complex with a Phosphate Ion and alpha-Benzylaminobenzylphosphonic Acid Update the Mechanistic Picture and Offer New Insights into Inhibitor Design | PDB:1ND5 | ||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [1] |
| PDB Sequence |
KELKFVTLVF
10 RHGDRSPIDT20 FPTDPIKESS30 WPQGFGQLTQ40 LGMEQHYELG50 EYIRKRYRKF 60 LNESYKHEQV70 YIRSTDVDRT80 LMSAMTNLAA90 LFPPEGVSIW100 NPILLWQPIP 110 VHTVPLSEDQ120 LLYLPFRNCP130 RFQELESETL140 KSEEFQKRLH150 PYKDFIATLG 160 KLSGLHGQDL170 FGIWSKVYDP180 LYCESVHNFT190 LPSWATEDTM200 TKLRELSELS 210 LLSLYGIHKQ220 KEKSRLQGGV230 LVNEILNHMK240 RATQIPSYKK250 LIMYSAHDTT 260 VSGLQMALDV270 YNGLLPPYAS280 CHLTELYFEK290 GEYFVEMYYR300 NETQHEPYPL 310 MLPGCSPSCP320 LERFAELVGP330 VIPQDWSTEC340 MT
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| Ligand Name: n-Propyl-tartramic acid | Ligand Info | |||||
| Structure Description | STRUCTURAL ORIGINS OF L(+)-TARTRATE INHIBITION OF HUMAN PROSTATIC ACID PHOSPHATASE | PDB:2HPA | ||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [2] |
| PDB Sequence |
KELKFVTLVF
1010 RHGDRSPIDT1020 FPTDPIKESS1030 WPQGFGQLTQ1040 LGMEQHYELG1050 EYIRKRYRKF 1060 LNESYKHEQV1070 YIRSTDVDRT1080 LMSAMTNLAA1090 LFPPEGVSIW1100 NPILLWQPIP 1110 VHTVPLSEDQ1120 LLYLPFRNCP1130 RFQELESETL1140 KSEEFQKRLH1150 PYKDFIATLG 1160 KLSGLHGQDL1170 FGIWSKVYDP1180 LYCESVHNFT1190 LPSWATEDTM1200 TKLRELSELS 1210 LLSLYGIHKQ1220 KEKSRLQGGV1230 LVNEILNHMK1240 RATQIPSYKK1250 LIMYSAHDTT 1260 VSGLQMALDV1270 YNGLLPPYAS1280 CHLTELYFEK1290 GEYFVEMYYR1300 NETQHEPYPL 1310 MLPGCSPSCP1320 LERFAELVGP1330 VIPQDWSTEC1340 MT
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design. Biochemistry. 2003 Jan 21;42(2):383-9. | ||||
| REF 2 | Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase. J Biol Chem. 1998 Nov 13;273(46):30406-9. | ||||
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