Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92794 | Target Info | |||
| Target Name | Urea transporter 1 (SLC14A1) | ||||
| Synonyms | Urea transporter, erythrocyte; UTE; UT1; Solute carrier family 14 member 1; RACH1; JK; HUT11 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SLC14A1 | ||||
| Biochemical Class | Urea transporter family | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: B-Octylglucoside | Ligand Info | |||||
| Structure Description | X-ray Structure of the Human Urea Channel SLC14A1/UT1 | PDB:6QD5 | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
FPKALGYVTG
40 DMKELANQLK50 DKPVVLQFID60 WILRGISQVV70 FVNNPVSGIL80 ILVGLLVQNP 90 WWALTGWLGT100 VVSTLMALLL110 SQDRSLIASG120 LYGYNATLVG130 VLMAVFSDKG 140 DYFWWLLLPV150 CAMSMTCPIF160 SSALNSVLSK170 WDLPVFTLPF180 NMALSMYLSA 190 TGHYNPFFPA200 KLVIPITTAP210 QISWSDLSAL220 ELLKSIPVGV230 GQIYGCDNPW 240 TGGIFLGAIL250 LSSPLMCLHA260 AIGSLLGIAA270 GLSLSAPFEN280 IYFGLWGFNS 290 SLACIAMGGM300 FMALTWQTHL310 LALGCALFTA320 YLGVGMANFM330 AEVGLPACTW 340 PFCLATLLFL350 IMTTKNSNIY360 KMPLSKVTYP370 EENRIFYLQA380 KKRMVE |
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ALA34
3.942
TYR37
3.833
GLU44
4.356
GLN48
3.976
GLN68
2.964
PHE71
3.657
ASN73
3.906
PRO90
4.903
LEU94
3.829
LEU105
3.910
LEU108
2.589
LEU109
4.207
SER111
3.057
ARG114
3.814
LEU116
3.843
LEU121
3.715
TYR122
3.400
LYS139
2.824
TYR142
3.061
PHE143
3.618
TRP144
2.872
|
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| Ligand Name: Cholesterol hemisuccinate | Ligand Info | |||||
| Structure Description | X-ray Structure of the Human Urea Channel SLC14A1/UT1 | PDB:6QD5 | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
FPKALGYVTG
40 DMKELANQLK50 DKPVVLQFID60 WILRGISQVV70 FVNNPVSGIL80 ILVGLLVQNP 90 WWALTGWLGT100 VVSTLMALLL110 SQDRSLIASG120 LYGYNATLVG130 VLMAVFSDKG 140 DYFWWLLLPV150 CAMSMTCPIF160 SSALNSVLSK170 WDLPVFTLPF180 NMALSMYLSA 190 TGHYNPFFPA200 KLVIPITTAP210 QISWSDLSAL220 ELLKSIPVGV230 GQIYGCDNPW 240 TGGIFLGAIL250 LSSPLMCLHA260 AIGSLLGIAA270 GLSLSAPFEN280 IYFGLWGFNS 290 SLACIAMGGM300 FMALTWQTHL310 LALGCALFTA320 YLGVGMANFM330 AEVGLPACTW 340 PFCLATLLFL350 IMTTKNSNIY360 KMPLSKVTYP370 EENRIFYLQA380 KKRMVE |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | X-ray Structure of the Human Urea Channel SLC14A1/UT1 | ||||
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