Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92460 | Target Info | |||
| Target Name | Guanine deaminase (GDA) | ||||
| Synonyms | p51-nedasin; KIAA1258; Guanine aminohydrolase; Guanase; GAH | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | GDA | ||||
| Biochemical Class | Metallo-dependent hydrolase superfamily. ATZ/TRZ family | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Valaciclovir | Ligand Info | |||||
| Structure Description | HUMAN GUANINE DEAMINASE IN COMPLEX WITH VALACYCLOVIR | PDB:4AQL | ||||
| Method | X-ray diffraction | Resolution | 1.99 Å | Mutation | No | [1] |
| PDB Sequence |
LAHIFRGTFV
18 HSTWTCPMEV28 LRDHLLGVSD38 SGKIVFLEEA48 SQQEKLAKEW58 CFKPCEIREL 68 SHHEFFMPGL78 VDTHIHASQY88 SFAGSSIDLP98 LLEWLTKYTF108 PAEHRFQNID 118 FAEEVYTRVV128 RRTLKNGTTT138 ACYFATIHTD148 SSLLLADITD158 KFGQRAFVGK 168 VCMDLNDTFP178 EYKETTEESI188 KETERFVSEM198 LQKNYSRVKP208 IVTPRFSLSC 218 SETLMGELGN228 IAKTRDLHIQ238 SHISENRDEV248 EAVKNLYPSY258 KNYTSVYDKN 268 NLLTNKTVMA278 HGCYLSAEEL288 NVFHERGASI298 AHCPNSNLSL308 SSGFLNVLEV 318 LKHEVKIGLG328 TDVAGGYSYS338 MLDAIRRAVM348 VSNILLINKV358 NEKSLTLKEV 368 FRLATLGGSQ378 ALGLDGEIGN388 FEVGKEFDAI398 LINPKASDSP408 IDLFYGDFFG 418 DISEAVIQKF428 LYLGDDRNIE438 EVYVGGKQVV448 PF
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HIS84
3.424
GLN87
2.948
LEU99
3.088
LEU100
2.849
TRP102
3.827
LEU103
3.503
THR107
4.008
GLU111
4.645
ARG213
2.848
PHE214
3.059
LEU216
3.595
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| Ligand Name: Xanthine | Ligand Info | |||||
| Structure Description | Human guanine deaminase (guaD) in complex with zinc and its product Xanthine. | PDB:2UZ9 | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [2] |
| PDB Sequence |
PLAHIFRGTF
17 VHSTWTCPME27 VLRDHLLGVS37 DSGKIVFLEE47 ASQQEKLAKE57 WCFKPCEIRE 67 LSHHEFFMPG77 LVDTHIHASQ87 YSFAGSSIDL97 PLLEWLTKYT107 FPAEHRFQNI 117 DFAEEVYTRV127 VRRTLKNGTT137 TACYFATIHT147 DSSLLLADIT157 DKFGQRAFVG 167 KVCMDLNDTF177 PEYKETTEES187 IKETERFVSE197 MLQKNYSRVK207 PIVTPRFSLS 217 CSETLMGELG227 NIAKTRDLHI237 QSHISENRDE247 VEAVKNLYPS257 YKNYTSVYDK 267 NNLLTNKTVM277 AHGCYLSAEE287 LNVFHERGAS297 IAHCPNSNLS307 LSSGFLNVLE 317 VLKHEVKIGL327 GTDVAGGYSY337 SMLDAIRRAV347 MVSNILLINK357 VNEKSLTLKE 367 VFRLATLGGS377 QALGLDGEIG387 NFEVGKEFDA397 ILINPKASDS407 PIDLFYGDFF 417 GDISEAVIQK427 FLYLGDDRNI437 EEVYVGGKQV447 VPFS
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism. PLoS One. 2012;7(5):e37724. | ||||
| REF 2 | Human Guanine Deaminase (Guad) in Complex with Zinc and its Product Xhantine | ||||
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