Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92334 | Target Info | |||
| Target Name | Mixed lineage kinase 4 (MAP3K21) | ||||
| Synonyms | Mitogen-activated protein kinase kinase kinase MLK4; MLK4beta | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | MAP3K21 | ||||
| Biochemical Class | Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Phosphothiophosphoric acid-adenylate ester | Ligand Info | |||||
| Structure Description | Structure of MLK4 kinase domain with ATPgammaS | PDB:4UYA | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
SPVHVAFERL
124 ELKELIGAGQ137 VYRATWQGQE147 VAVKAAAAES167 VRREARLFAM177 LRHPNIIELR 187 GVCLQQPHLC197 LVLEFARGGA207 LNRALAGRRI232 PPHVLVNWAV242 QIARGMLYLH 252 EEAFVPILHR262 DLKSSNILLL272 EKIEHDICNK283 TLKITDFGAY308 AWMAPEVIKS 318 SLFSKGSDIW328 SYGVLLWELL338 TGEVPYRGID348 GLAVAYGVAV358 NKLTLPIPST 368 CPEPFAKLMK378 ECWQQDPHIR388 PSFALILEQL398 TAMTEMPQES413 FHSMQDDWKL 423 EIQQMFDELR433 TKEK
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis. Cancer Res. 2016 Feb 1;76(3):724-35. | ||||
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