Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T91451 | Target Info | |||
| Target Name | E2 ubiquitin-conjugating enzyme T (UBE2T) | ||||
| Synonyms | Ubiquitin-protein ligase T; Ubiquitin carrier protein T; Cell proliferation-inducing gene 50 protein | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | UBE2T | ||||
| Biochemical Class | Ubiquitin-conjugating enzyme family | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 1,3-Benzothiazol-2-ylmethylamine | Ligand Info | |||||
| Structure Description | Ube2T in complex with fragment EM04 | PDB:5NGZ | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [1] |
| PDB Sequence |
QRASRLKREL
11 HMLATEPPPG21 ITCWQDKDQM31 DDLRAQILGG41 ANTPYEKGVF51 KLEVIIPERY 61 PFEPPQIRFL71 TPIYHPNIDS81 AGRICLDVLK91 LPPKGAWRPS101 LNIATVLTSI 111 QLLMSEPNPD121 DPLMADISSE131 FKYNKPAFLK141 NARQWTEKHA151 RQ |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening. J Med Chem. 2017 May 11;60(9):4093-4098. | ||||
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