Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T91286 Target Info
Target Name Metalloreductase STEAP1 (STEAP1)
Synonyms Sixtransmembrane epithelial antigen of prostate 1; STEAP1
Target Type Clinical trial Target
Gene Name STEAP1
Biochemical Class Metal ion oxidoreductase
UniProt ID
STEA1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 1,2-Dimyristoyl-Sn-Glycero-3-Phosphate Ligand Info
Structure Description Cryo-EM structure of trimeric human STEAP1 bound to three Fab120.545 fragments PDB:6Y9B
Method Electron microscopy Resolution 2.97 Å Mutation No [1]
PDB Sequence
LFPQWHLPIK
76
IAAIIASLTF
86
LYTLLREVIH
96
PLATSHQQYF
106
YKIPILVINK
116

VLPMVSITLL
126
ALVYLPGVIA
136
AIVQLHNGTK
148
KFPHWLDKWM
158
LTRKQFGLLS
168

FFFAVLHAIY
178
SLSYPMRRSY
188
RYKLLNWAYQ
198
QVQQNKEDAW
208
IEHDVWRMEI
218

YVSLGIVGLA
228
ILALLAVTSI
238
PSVSDSLTWR
248
EFHYIQSKLG
258
IVSLLLGTIH
268

ALIFAWNKWI
278
DIKQFVWYTP
288
PTFMIAVFLP
298
IVVLIFKSIL
308
FLPC
Residue
Distance (Å)
PHE68
3.279
GLN70
2.897
TRP71
3.408
LYS162
3.772
GLN163
4.248
LEU166
4.085
PHE169
3.802
PHE170
3.589
VAL173
3.551
Residue
Distance (Å)
LEU174
4.971
ILE177
4.707
ALA231
4.770
ALA234
3.477
VAL235
4.435
SER237
2.896
ILE238
3.981
PRO239
3.525
References  Top
REF 1 Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1 (STEAP1). J Biol Chem. 2020 Jul 10;295(28):9502-9512.

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