Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T91001 | Target Info | |||
| Target Name | Bacterial Elongation factor Tu (Bact EFTu) | ||||
| Synonyms | tufA; P43; Elongation factor Tu 1; EFTu 1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | Bact EFTu | ||||
| Biochemical Class | GTP-binding elongation factor family | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Tetracycline | Ligand Info | |||||
| Structure Description | Trypsin-modified Elongation Factor Tu in complex with tetracycline | PDB:2HCJ | ||||
| Method | X-ray diffraction | Resolution | 2.12 Å | Mutation | Yes | [1] |
| PDB Sequence |
> Chain A
TKPHVNVGTI 17 GHVDHGKTTL27 TAAITTVLAK37 TYG> Chain B GITINTSHVE 68 YDTPTRHYAH78 VDPGHADYVK89 NMITGAAQMD99 GAILVVAATD109 GPMPQTREHI 119 LLGRQVGVPY129 IIVFLNKCDM139 VDDEELLELV149 EMEVRELLSQ159 YDFPGDDTPI 169 VRGSALKALE179 GDAEWEAKIL189 ELAGFLDSYI199 PEPERAIDKP209 FLLPIEDVFS 219 ISGRGTVVTG229 RVERGIIKVG239 EEVEIVGIKE249 TQKSTCTGVE259 MFRKLLDEGR 269 AGENVGVLLR279 GIKREEIERG289 QVLAKPGTIK299 PHTKFESEVY309 ILSKDEGGRH 319 TPFFKGYRPQ329 FYFRTTDVTG339 TIELPEGVEM349 VMPGDNIKMV359 VTLIHPIAMD 369 DGLRFAIREG379 GRTVGAGVVA389 KVLG
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Guanosine-5'-Diphosphate | Ligand Info | |||||
| Structure Description | Elongation factor Tu:Ts complex with partially bound GDP | PDB:4PC3 | ||||
| Method | X-ray diffraction | Resolution | 1.83 Å | Mutation | No | [2] |
| PDB Sequence |
TKPHVNVGTI
17 GHVDHGKTTL27 TAAITTVLAK37 TYGGSHVEYD70 TPTRHYAHVD80 CPGHADYVKN 90 MITGAAQMDG100 AILVVAATDG110 PMPQTREHIL120 LGRQVGVPYI130 IVFLNKCDMV 140 DDEELLELVE150 MEVRELLSQY160 DFPGDDTPIV170 RGSALKALEG180 DAEWEAKILE 190 LAGFLDSYIP200 EPERAIDKPF210 LLPIEDVFSI220 SGRGTVVTGR230 VERGIIKVGE 240 EVEIVGIKET250 QKSTCTGVEM260 FRKLLDEGRA270 GENVGVLLRG280 IKREEIERGQ 290 VLAKPGTIKP300 HTKFESEVYI310 LSKDEGGRHT320 PFFKGYRPQF330 YFRTTDVTGT 340 IELPEGVEMV350 MPGDNIKMVV360 TLIHPIAMDD370 GLRFAIREGG380 RTVGAGVVAK 390 VLG
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Cysteine Sulfenic Acid | Ligand Info | |||||
| Structure Description | Trypsin-modified Elongation Factor Tu in complex with tetracycline | PDB:2HCJ | ||||
| Method | X-ray diffraction | Resolution | 2.12 Å | Mutation | Yes | [1] |
| PDB Sequence |
> Chain A
TKPHVNVGTI 17 GHVDHGKTTL27 TAAITTVLAK37 TYG> Chain B GITINTSHVE 68 YDTPTRHYAH78 VDPGHADYVK89 NMITGAAQMD99 GAILVVAATD109 GPMPQTREHI 119 LLGRQVGVPY129 IIVFLNKCDM139 VDDEELLELV149 EMEVRELLSQ159 YDFPGDDTPI 169 VRGSALKALE179 GDAEWEAKIL189 ELAGFLDSYI199 PEPERAIDKP209 FLLPIEDVFS 219 ISGRGTVVTG229 RVERGIIKVG239 EEVEIVGIKE249 TQKSTCTGVE259 MFRKLLDEGR 269 AGENVGVLLR279 GIKREEIERG289 QVLAKPGTIK299 PHTKFESEVY309 ILSKDEGGRH 319 TPFFKGYRPQ329 FYFRTTDVTG339 TIELPEGVEM349 VMPGDNIKMV359 VTLIHPIAMD 369 DGLRFAIREG379 GRTVGAGVVA389 KVLG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSO or .CSO2 or .CSO3 or :3CSO;style chemicals stick;color identity;select .A:16 or .A:24 or .B:63 or .B:64 or .B:79 or .B:80 or .B:82 or .B:83 or .B:86 or .B:87 or .B:90; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Glyoxalate, Glyoxylate | Ligand Info | |||||
| Structure Description | Trypsin-modified Elongation Factor Tu in complex with tetracycline | PDB:2HCJ | ||||
| Method | X-ray diffraction | Resolution | 2.12 Å | Mutation | Yes | [1] |
| PDB Sequence |
GITINTSHVE
68 YDTPTRHYAH78 VDPGHADYVK89 NMITGAAQMD99 GAILVVAATD109 GPMPQTREHI 119 LLGRQVGVPY129 IIVFLNKCDM139 VDDEELLELV149 EMEVRELLSQ159 YDFPGDDTPI 169 VRGSALKALE179 GDAEWEAKIL189 ELAGFLDSYI199 PEPERAIDKP209 FLLPIEDVFS 219 ISGRGTVVTG229 RVERGIIKVG239 EEVEIVGIKE249 TQKSTCTGVE259 MFRKLLDEGR 269 AGENVGVLLR279 GIKREEIERG289 QVLAKPGTIK299 PHTKFESEVY309 ILSKDEGGRH 319 TPFFKGYRPQ329 FYFRTTDVTG339 TIELPEGVEM349 VMPGDNIKMV359 VTLIHPIAMD 369 DGLRFAIREG379 GRTVGAGVVA389 KVLG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GLV or .GLV2 or .GLV3 or :3GLV;style chemicals stick;color identity;select .B:261 or .B:262; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (2Z)-2-amino-3-sulfanylbut-2-enoic acid | Ligand Info | |||||
| Structure Description | EF-TU (ESCHERICHIA COLI) IN COMPLEX WITH THIOMURACIN ANALOG | PDB:5JBQ | ||||
| Method | X-ray diffraction | Resolution | 2.01 Å | Mutation | No | [3] |
| PDB Sequence |
KEKFERTKPH
11 VNVGTIGHVD21 HGKTTLTAAI31 TTVLAKTYGG41 AARAFDQIDN51 APEEKARGIT 61 INTSHVEYDT71 PTRHYAHVDC81 PGHADYVKNM91 ITGAAQMDGA101 ILVVAATDGP 111 MPQTREHILL121 GRQVGVPYII131 VFLNKCDMVD141 DEELLELVEM151 EVRELLSQYD 161 FPGDDTPIVR171 GSALKALEGD181 AEWEAKILEL191 AGFLDSYIPE201 PERAIDKPFL 211 LPIEDVFSIS221 GRGTVVTGRV231 ERGIIKVGEE241 VEIVGIKETQ251 KSTCTGVEMF 261 RKLLDEGRAG271 ENVGVLLRGI281 KREEIERGQV291 LAKPGTIKPH301 TKFESEVYIL 311 SKDEGGRHTP321 FFKGYRPQFY331 FRTTDVTGTI341 ELPEGVEMVM351 PGDNIKMVVT 361 LIHPIAMDDG371 LRFAIREGGR381 TVGAGVVAKV391 LG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BB6 or .BB62 or .BB63 or :3BB6;style chemicals stick;color identity;select .A:261 or .A:262; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (2Z)-2-amino-3-sulfanylprop-2-enoic acid | Ligand Info | |||||
| Structure Description | EF-TU (ESCHERICHIA COLI) IN COMPLEX WITH THIOMURACIN ANALOG | PDB:5JBQ | ||||
| Method | X-ray diffraction | Resolution | 2.01 Å | Mutation | No | [3] |
| PDB Sequence |
KEKFERTKPH
11 VNVGTIGHVD21 HGKTTLTAAI31 TTVLAKTYGG41 AARAFDQIDN51 APEEKARGIT 61 INTSHVEYDT71 PTRHYAHVDC81 PGHADYVKNM91 ITGAAQMDGA101 ILVVAATDGP 111 MPQTREHILL121 GRQVGVPYII131 VFLNKCDMVD141 DEELLELVEM151 EVRELLSQYD 161 FPGDDTPIVR171 GSALKALEGD181 AEWEAKILEL191 AGFLDSYIPE201 PERAIDKPFL 211 LPIEDVFSIS221 GRGTVVTGRV231 ERGIIKVGEE241 VEIVGIKETQ251 KSTCTGVEMF 261 RKLLDEGRAG271 ENVGVLLRGI281 KREEIERGQV291 LAKPGTIKPH301 TKFESEVYIL 311 SKDEGGRHTP321 FFKGYRPQFY331 FRTTDVTGTI341 ELPEGVEMVM351 PGDNIKMVVT 361 LIHPIAMDDG371 LRFAIREGGR381 TVGAGVVAKV391 LG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BB9 or .BB92 or .BB93 or :3BB9;style chemicals stick;color identity;select .A:216 or .A:218 or .A:220 or .A:226 or .A:228 or .A:230 or .A:256 or .A:257 or .A:258 or .A:259 or .A:260 or .A:261 or .A:262 or .A:264 or .A:273 or .A:274 or .A:275 or .A:276 or .A:277; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (3R,4R)-4-hydroxy-3-methyl-L-proline | Ligand Info | |||||
| Structure Description | EF-TU (ESCHERICHIA COLI) IN COMPLEX WITH THIOMURACIN ANALOG | PDB:5JBQ | ||||
| Method | X-ray diffraction | Resolution | 2.01 Å | Mutation | No | [3] |
| PDB Sequence |
KEKFERTKPH
11 VNVGTIGHVD21 HGKTTLTAAI31 TTVLAKTYGG41 AARAFDQIDN51 APEEKARGIT 61 INTSHVEYDT71 PTRHYAHVDC81 PGHADYVKNM91 ITGAAQMDGA101 ILVVAATDGP 111 MPQTREHILL121 GRQVGVPYII131 VFLNKCDMVD141 DEELLELVEM151 EVRELLSQYD 161 FPGDDTPIVR171 GSALKALEGD181 AEWEAKILEL191 AGFLDSYIPE201 PERAIDKPFL 211 LPIEDVFSIS221 GRGTVVTGRV231 ERGIIKVGEE241 VEIVGIKETQ251 KSTCTGVEMF 261 RKLLDEGRAG271 ENVGVLLRGI281 KREEIERGQV291 LAKPGTIKPH301 TKFESEVYIL 311 SKDEGGRHTP321 FFKGYRPQFY331 FRTTDVTGTI341 ELPEGVEMVM351 PGDNIKMVVT 361 LIHPIAMDDG371 LRFAIREGGR381 TVGAGVVAKV391 LG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .05N or .05N2 or .05N3 or :305N;style chemicals stick;color identity;select .A:215 or .A:216 or .A:228 or .A:229 or .A:273; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 3-Hydroxy-2-Iminopropanoic Acid | Ligand Info | |||||
| Structure Description | EF-TU (ESCHERICHIA COLI) IN COMPLEX WITH THIOMURACIN ANALOG | PDB:5JBQ | ||||
| Method | X-ray diffraction | Resolution | 2.01 Å | Mutation | No | [3] |
| PDB Sequence |
KEKFERTKPH
11 VNVGTIGHVD21 HGKTTLTAAI31 TTVLAKTYGG41 AARAFDQIDN51 APEEKARGIT 61 INTSHVEYDT71 PTRHYAHVDC81 PGHADYVKNM91 ITGAAQMDGA101 ILVVAATDGP 111 MPQTREHILL121 GRQVGVPYII131 VFLNKCDMVD141 DEELLELVEM151 EVRELLSQYD 161 FPGDDTPIVR171 GSALKALEGD181 AEWEAKILEL191 AGFLDSYIPE201 PERAIDKPFL 211 LPIEDVFSIS221 GRGTVVTGRV231 ERGIIKVGEE241 VEIVGIKETQ251 KSTCTGVEMF 261 RKLLDEGRAG271 ENVGVLLRGI281 KREEIERGQV291 LAKPGTIKPH301 TKFESEVYIL 311 SKDEGGRHTP321 FFKGYRPQFY331 FRTTDVTGTI341 ELPEGVEMVM351 PGDNIKMVVT 361 LIHPIAMDDG371 LRFAIREGGR381 TVGAGVVAKV391 LG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MH6 or .MH62 or .MH63 or :3MH6;style chemicals stick;color identity;select .A:218 or .A:220 or .A:226 or .A:259 or .A:262 or .A:275; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: L-threo-3-Phenylserine | Ligand Info | |||||
| Structure Description | EF-TU (ESCHERICHIA COLI) IN COMPLEX WITH THIOMURACIN ANALOG | PDB:5JBQ | ||||
| Method | X-ray diffraction | Resolution | 2.01 Å | Mutation | No | [3] |
| PDB Sequence |
KEKFERTKPH
11 VNVGTIGHVD21 HGKTTLTAAI31 TTVLAKTYGG41 AARAFDQIDN51 APEEKARGIT 61 INTSHVEYDT71 PTRHYAHVDC81 PGHADYVKNM91 ITGAAQMDGA101 ILVVAATDGP 111 MPQTREHILL121 GRQVGVPYII131 VFLNKCDMVD141 DEELLELVEM151 EVRELLSQYD 161 FPGDDTPIVR171 GSALKALEGD181 AEWEAKILEL191 AGFLDSYIPE201 PERAIDKPFL 211 LPIEDVFSIS221 GRGTVVTGRV231 ERGIIKVGEE241 VEIVGIKETQ251 KSTCTGVEMF 261 RKLLDEGRAG271 ENVGVLLRGI281 KREEIERGQV291 LAKPGTIKPH301 TKFESEVYIL 311 SKDEGGRHTP321 FFKGYRPQFY331 FRTTDVTGTI341 ELPEGVEMVM351 PGDNIKMVVT 361 LIHPIAMDDG371 LRFAIREGGR381 TVGAGVVAKV391 LG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .H14 or .H142 or .H143 or :3H14;style chemicals stick;color identity;select .A:261; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: trans-4-Aminocyclohexanecarboxylic acid | Ligand Info | |||||
| Structure Description | EF-TU (ESCHERICHIA COLI) IN COMPLEX WITH THIOMURACIN ANALOG | PDB:5JBQ | ||||
| Method | X-ray diffraction | Resolution | 2.01 Å | Mutation | No | [3] |
| PDB Sequence |
KEKFERTKPH
11 VNVGTIGHVD21 HGKTTLTAAI31 TTVLAKTYGG41 AARAFDQIDN51 APEEKARGIT 61 INTSHVEYDT71 PTRHYAHVDC81 PGHADYVKNM91 ITGAAQMDGA101 ILVVAATDGP 111 MPQTREHILL121 GRQVGVPYII131 VFLNKCDMVD141 DEELLELVEM151 EVRELLSQYD 161 FPGDDTPIVR171 GSALKALEGD181 AEWEAKILEL191 AGFLDSYIPE201 PERAIDKPFL 211 LPIEDVFSIS221 GRGTVVTGRV231 ERGIIKVGEE241 VEIVGIKETQ251 KSTCTGVEMF 261 RKLLDEGRAG271 ENVGVLLRGI281 KREEIERGQV291 LAKPGTIKPH301 TKFESEVYIL 311 SKDEGGRHTP321 FFKGYRPQFY331 FRTTDVTGTI341 ELPEGVEMVM351 PGDNIKMVVT 361 LIHPIAMDDG371 LRFAIREGGR381 TVGAGVVAKV391 LG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6RK or .6RK2 or .6RK3 or :36RK;style chemicals stick;color identity;select .A:220 or .A:223 or .A:264 or .A:277; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: trans-4-({[(E)-1-amino-2-sulfanylethenyl]carbamoyl}oxy)cyclohexanecarboxylic acid | Ligand Info | |||||
| Structure Description | Ef-tu (escherichia coli) in complex with nvp-ldk733 | PDB:3U6K | ||||
| Method | X-ray diffraction | Resolution | 2.45 Å | Mutation | No | [4] |
| PDB Sequence |
TKPHVNVGTI
17 GHVDHGKTTL27 TAAITTVLAK37 TYGGAARAFD47 QIDNAPEEKA57 RGITINTSHV 67 EYDTPTRHYA77 HVDCPGHADY87 VKNMITGAAQ97 MDGAILVVAA107 TDGPMPQTRE 117 HILLGRQVGV127 PYIIVFLNKC137 DMVDDEELLE147 LVEMEVRELL157 SQYDFPGDDT 167 PIVRGSALKA177 LEGDAEWEAK187 ILELAGFLDS197 YIPEPERAID207 KPFLLPIEDV 217 FSISGRGTVV227 TGRVERGIIK237 VGEEVEIVGI247 KETQKSTCTG257 VEMFRKLLDE 267 GRAGENVGVL277 LRGIKREEIE287 RGQVLAKPGT297 IKPHTKFESE307 VYILSKDEGG 317 RHTPFFKGYR327 PQFYFRTTDV337 TGTIELPEGV347 EMVMPGDNIK357 MVVTLIHPIA 367 MDDGLRFAIR377 EGGRTVGAGV387 VAKVLG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .9BB or .9BB2 or .9BB3 or :39BB;style chemicals stick;color identity;select .A:220 or .A:223 or .A:226 or .A:256 or .A:257 or .A:258 or .A:259 or .A:264 or .A:275 or .A:276 or .A:277; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: trans-4-({[(E)-1-amino-2-sulfanylethenyl](4-carboxybutyl)carbamoyl}oxy)cyclohexanecarboxylic acid | Ligand Info | |||||
| Structure Description | EF-Tu (Escherichia coli) in complex with NVP-LFF571 | PDB:3U2Q | ||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [5] |
| PDB Sequence |
ERTKPHVNVG
15 TIGHVDHGKT25 TLTAAITTVL35 AKTYGGAARA45 FDQIDNAPEE55 KATINTSHVE 68 YDTPTRHYAH78 VDCPGHADYV88 KNMITGAAQM98 DGAILVVAAT108 DGPMPQTREH 118 ILLGRQVGVP128 YIIVFLNKCD138 MVDDEELLEL148 VEMEVRELLS158 QYDFPGDDTP 168 IVRGSALKAL178 EGDAEWEAKI188 LELAGFLDSY198 IPEPERAIDK208 PFLLPIEDVF 218 SISGRGTVVT228 GRVERGIIKV238 GEEVEIVGIK248 ETQKSTCTGV258 EMFRKLLDEG 268 RAGENVGVLL278 RGIKREEIER288 GQVLAKPGTI298 KPHTKFESEV308 YILSKDEGGR 318 HTPFFKGYRP328 QFYFRTTDVT338 GTIELPEGVE348 MVMPGDNIKM358 VVTLIHPIAM 368 DDGLRFAIRE378 GGRTVGAGVV388 AKVLG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .7BB or .7BB2 or .7BB3 or :37BB;style chemicals stick;color identity;select .A:220 or .A:223 or .A:226 or .A:256 or .A:257 or .A:258 or .A:259 or .A:264 or .A:275 or .A:276 or .A:277; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (1S,2S,3E,5E,7E,10S,11S,12S)-12-[(2R,4E,6E,8Z,10R,12E,14E,16Z,18S,19Z)-10,18-Dihydroxy-12,16,19-trimethyl-11,22-dioxooxacyclodocosa-4,6,8,12,14,16,19-heptaen-2-YL]-2,11-dihydroxy-1,10-dimethyl-9-oxotrideca-3,5,7-trien-1-YL 6-deoxy-2,4-DI-O-methyl-beta-L-galactopyranoside | Ligand Info | |||||
| Structure Description | Elongation factor Tu:Ts complex in a near GTP conformation. | PDB:4PC7 | ||||
| Method | X-ray diffraction | Resolution | 3.60 Å | Mutation | No | [2] |
| PDB Sequence |
TKPHVNVGTI
17 GHVDHGKTTL27 TAAITTVLAK37 TYGGTINTSH66 VEYDTPTRHY76 AHVDCPGHAD 86 YVKNMITGAA96 QMDGAILVVA106 ATDGPMPQTR116 EHILLGRQVG126 VPYIIVFLNK 136 CDMVDDEELL146 ELVEMEVREL156 LSQYDFPGDD166 TPIVRGSALK176 ALEGDAEWEA 186 KILELAGFLD196 SYIPEPERAI206 DKPFLLPIED216 VFSISGRGTV226 VTGRVERGII 236 KVGEEVEIVG246 IKETQKSTCT256 GVEMFRKLLD266 EGRAGENVGV276 LLRGIKREEI 286 ERGQVLAKPG296 TIKPHTKFES306 EVYILSKDEG316 GRHTPFFKGY326 RPQFYFRTTD 336 VTGTIELPEG346 VEMVMPGDNI356 KMVVTLIHPI366 AMDDGLRFAI376 REGGRTVGAG 386 VVAKVLG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PUL or .PUL2 or .PUL3 or :3PUL;style chemicals stick;color identity;select .A:63 or .A:88 or .A:89 or .A:92 or .A:93 or .A:96 or .A:97 or .A:121 or .A:124 or .A:125 or .A:126 or .A:213 or .A:215 or .A:218 or .A:220 or .A:226 or .A:228 or .A:229 or .A:230 or .A:259 or .A:260 or .A:261 or .A:262 or .A:273 or .A:274 or .A:275 or .A:288 or .A:331 or .A:332 or .A:333 or .A:334 or .A:372 or .A:373 or .A:374 or .A:375 or .A:377 or .A:382; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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ASN63
4.063
VAL88
3.830
LYS89
4.094
ILE92
3.443
THR93
3.574
ALA96
3.701
GLN97
3.317
LEU121
3.820
GLN124
3.472
VAL125
3.613
GLY126
4.942
PRO213
3.690
GLU215
2.393
PHE218
3.708
ILE220
3.834
VAL226
4.958
THR228
3.529
GLY229
3.297
ARG230
3.493
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| Ligand Name: Phosphoaminophosphonic acid-guanylate ester | Ligand Info | |||||
| Structure Description | Elongation factor Tu:Ts complex in a near GTP conformation. | PDB:4PC7 | ||||
| Method | X-ray diffraction | Resolution | 3.60 Å | Mutation | No | [2] |
| PDB Sequence |
TKPHVNVGTI
17 GHVDHGKTTL27 TAAITTVLAK37 TYGGTINTSH66 VEYDTPTRHY76 AHVDCPGHAD 86 YVKNMITGAA96 QMDGAILVVA106 ATDGPMPQTR116 EHILLGRQVG126 VPYIIVFLNK 136 CDMVDDEELL146 ELVEMEVREL156 LSQYDFPGDD166 TPIVRGSALK176 ALEGDAEWEA 186 KILELAGFLD196 SYIPEPERAI206 DKPFLLPIED216 VFSISGRGTV226 VTGRVERGII 236 KVGEEVEIVG246 IKETQKSTCT256 GVEMFRKLLD266 EGRAGENVGV276 LLRGIKREEI 286 ERGQVLAKPG296 TIKPHTKFES306 EVYILSKDEG316 GRHTPFFKGY326 RPQFYFRTTD 336 VTGTIELPEG346 VEMVMPGDNI356 KMVVTLIHPI366 AMDDGLRFAI376 REGGRTVGAG 386 VVAKVLG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:19 or .A:20 or .A:21 or .A:22 or .A:23 or .A:24 or .A:25 or .A:26 or .A:80 or .A:81 or .A:82 or .A:83 or .A:84 or .A:135 or .A:136 or .A:138 or .A:139 or .A:173 or .A:174 or .A:175 or .A:176; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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HIS19
4.295
VAL20
3.582
ASP21
3.165
HIS22
3.495
GLY23
3.038
LYS24
2.216
THR25
2.581
THR26
3.058
ASP80
4.632
CYS81
3.768
PRO82
3.644
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| Ligand Name: (2S,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF ELONGATION FACTOR, TU (EF-TU-MGGDP) COMPLEXED WITH GE2270A, A THIAZOLYL PEPTIDE ANTIBIOTIC | PDB:1D8T | ||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | No | [6] |
| PDB Sequence |
EKFERTKPHV
12 NVGTIGHVDH22 GKTTLTAAIT32 TVLAKTYGGA42 ARAFDQIDNA52 PEEKARGITI 62 NTSHVEYDTP72 TRHYAHVDCP82 GHADYVKNMI92 TGAAQMDGAI102 LVVAATDGPM 112 PQTREHILLG122 RQVGVPYIIV132 FLNKCDMVDD142 EELLELVEME152 VRELLSQYDF 162 PGDDTPIVRG172 SALKALEGDA182 EWEAKILELA192 GFLDSYIPEP202 ERAIDKPFLL 212 PIEDVFSISG222 RGTVVTGRVE232 RGIIKVGEEV242 EIVGIKETQK252 STCTGVEMFR 262 KLLDEGRAGE272 NVGVLLRGIK282 REEIERGQVL292 AKPGTIKPHT302 KFESEVYILS 312 KDEGGRHTPF322 FKGYRPQFYF332 RTTDVTGTIE342 LPEGVEMVMP352 GDNIKMVVTL 362 IHPIAMDDGL372 RFAIREGGRT382 VGAGVVAKVL392 G
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BB8 or .BB82 or .BB83 or :3BB8;style chemicals stick;color identity;select .A:215 or .A:216 or .A:228 or .A:229 or .A:230 or .A:273; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (2Z)-2-amino-4-methoxy-3-sulfanylbut-2-enoic acid | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF ELONGATION FACTOR, TU (EF-TU-MGGDP) COMPLEXED WITH GE2270A, A THIAZOLYL PEPTIDE ANTIBIOTIC | PDB:1D8T | ||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | No | [6] |
| PDB Sequence |
EKFERTKPHV
12 NVGTIGHVDH22 GKTTLTAAIT32 TVLAKTYGGA42 ARAFDQIDNA52 PEEKARGITI 62 NTSHVEYDTP72 TRHYAHVDCP82 GHADYVKNMI92 TGAAQMDGAI102 LVVAATDGPM 112 PQTREHILLG122 RQVGVPYIIV132 FLNKCDMVDD142 EELLELVEME152 VRELLSQYDF 162 PGDDTPIVRG172 SALKALEGDA182 EWEAKILELA192 GFLDSYIPEP202 ERAIDKPFLL 212 PIEDVFSISG222 RGTVVTGRVE232 RGIIKVGEEV242 EIVGIKETQK252 STCTGVEMFR 262 KLLDEGRAGE272 NVGVLLRGIK282 REEIERGQVL292 AKPGTIKPHT302 KFESEVYILS 312 KDEGGRHTPF322 FKGYRPQFYF332 RTTDVTGTIE342 LPEGVEMVMP352 GDNIKMVVTL 362 IHPIAMDDGL372 RFAIREGGRT382 VGAGVVAKVL392 G
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BB7 or .BB72 or .BB73 or :3BB7;style chemicals stick;color identity;select .A:261 or .A:273; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: N-METHYL ASPARAGINE | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF ELONGATION FACTOR, TU (EF-TU-MGGDP) COMPLEXED WITH GE2270A, A THIAZOLYL PEPTIDE ANTIBIOTIC | PDB:1D8T | ||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | No | [6] |
| PDB Sequence |
EKFERTKPHV
12 NVGTIGHVDH22 GKTTLTAAIT32 TVLAKTYGGA42 ARAFDQIDNA52 PEEKARGITI 62 NTSHVEYDTP72 TRHYAHVDCP82 GHADYVKNMI92 TGAAQMDGAI102 LVVAATDGPM 112 PQTREHILLG122 RQVGVPYIIV132 FLNKCDMVDD142 EELLELVEME152 VRELLSQYDF 162 PGDDTPIVRG172 SALKALEGDA182 EWEAKILELA192 GFLDSYIPEP202 ERAIDKPFLL 212 PIEDVFSISG222 RGTVVTGRVE232 RGIIKVGEEV242 EIVGIKETQK252 STCTGVEMFR 262 KLLDEGRAGE272 NVGVLLRGIK282 REEIERGQVL292 AKPGTIKPHT302 KFESEVYILS 312 KDEGGRHTPF322 FKGYRPQFYF332 RTTDVTGTIE342 LPEGVEMVMP352 GDNIKMVVTL 362 IHPIAMDDGL372 RFAIREGGRT382 VGAGVVAKVL392 G
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MEN or .MEN2 or .MEN3 or :3MEN;style chemicals stick;color identity;select .A:260 or .A:261 or .A:262 or .A:273 or .A:274; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular complementarity between tetracycline and the GTPase active site of elongation factor Tu. Acta Crystallogr D Biol Crystallogr. 2006 Nov;62(Pt 11):1392-400. | ||||
| REF 2 | Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu. J Struct Biol. 2015 Jul;191(1):10-21. | ||||
| REF 3 | Antibacterial and Solubility Optimization of Thiomuracin A. J Med Chem. 2016 Jul 28;59(14):6920-8. | ||||
| REF 4 | Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids. J Med Chem. 2011 Dec 8;54(23):8099-109. | ||||
| REF 5 | Discovery of LFF571: an investigational agent for Clostridium difficile infection. J Med Chem. 2012 Mar 8;55(5):2376-87. | ||||
| REF 6 | Structure of an EF-Tu complex with a thiazolyl peptide antibiotic determined at 2.35 A resolution: atomic basis for GE2270A inhibition of EF-Tu. Biochemistry. 2000 Jan 11;39(1):37-45. | ||||
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