Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T90787 | Target Info | |||
| Target Name | NAPE-hydrolyzing phospholipase D (NAPE-PLD) | ||||
| Synonyms | NAPE-PLD; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; N-acyl phosphatidylethanolamine phospholipase D; C7orf18 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | NAPEPLD | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: ATX-101 | Ligand Info | |||||
| Structure Description | Structure of human NAPE-PLD | PDB:4QN9 | ||||
| Method | X-ray diffraction | Resolution | 2.65 Å | Mutation | No | [1] |
| PDB Sequence |
SKKGKDGRFV
66 NPWPTWKNPS76 IPNSSVPSSK97 EELDKELPVL107 KPYFITNPEE117 AGVREAGLRV 127 TWLGHATVMV137 EMDELIFLTD147 PIFSSRASPS157 QYMGPKRFRR167 SPCTISELPP 177 IDAVLISHNH187 YDHLDYNSVI197 ALNERFGNEL207 RWFVPLGLLD217 WMQKCGCENV 227 IELDWWEENC237 VPGHDKVTFV247 FTPSQHWCKR257 TLMDDNKVLW267 GSWSVLGPWN 277 RFFFAGDTGY287 CPAFEEIGKR297 FGPFDLAAIP307 IGAYEPRWFM317 KYQHVDPEEA 327 VRIHTDVQTK337 KSMAIHWGTF347 ALANEHYLEP357 PVKLNEALER367 YGLNAEDFFV 377 LKHGESRYLN387 N
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| Ligand Name: 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine | Ligand Info | |||||
| Structure Description | Structure of human NAPE-PLD | PDB:4QN9 | ||||
| Method | X-ray diffraction | Resolution | 2.65 Å | Mutation | No | [1] |
| PDB Sequence |
SKKGKDGRFV
66 NPWPTWKNPS76 IPNSSVPSSK97 EELDKELPVL107 KPYFITNPEE117 AGVREAGLRV 127 TWLGHATVMV137 EMDELIFLTD147 PIFSSRASPS157 QYMGPKRFRR167 SPCTISELPP 177 IDAVLISHNH187 YDHLDYNSVI197 ALNERFGNEL207 RWFVPLGLLD217 WMQKCGCENV 227 IELDWWEENC237 VPGHDKVTFV247 FTPSQHWCKR257 TLMDDNKVLW267 GSWSVLGPWN 277 RFFFAGDTGY287 CPAFEEIGKR297 FGPFDLAAIP307 IGAYEPRWFM317 KYQHVDPEEA 327 VRIHTDVQTK337 KSMAIHWGTF347 ALANEHYLEP357 PVKLNEALER367 YGLNAEDFFV 377 LKHGESRYLN387 N
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ALA154
3.409
SER155
4.052
PRO156
3.644
SER157
4.582
MET160
3.729
GLY161
4.528
PRO162
3.909
HIS185
4.590
HIS187
3.368
TYR188
3.005
ASP189
3.280
HIS190
4.337
HIS253
3.015
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids. Structure. 2015 Mar 3;23(3):598-604. | ||||
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