Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T89780 Target Info
Target Name Triggering receptor expressed on monocytes 1 (TREM1)
Synonyms Trem1; TREM-1
Target Type Literature-reported Target
Gene Name Trem1
UniProt ID
TREM1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Glutathione Ligand Info
Structure Description Crystal structure of the human myeloid cell activating receptor TREM-1 PDB:1Q8M
Method X-ray diffraction Resolution 2.60 Å Mutation No [1]
PDB Sequence
MELRAATKLT
25
EEKYELKEGQ
35
TLDVKCDYTL
45
EKFASSQKAW
55
QIIRDGEMPK
65

TLACTERPSK
75
NSHPVQVGRI
85
ILEDYHDHGL
95
LRVRMVNLQV
105
EDSGLYQCVI
115

YQPPKEPHML
125
FDRIRLVVTL
135
E
Residue
Distance (Å)
GLN52
2.453
THR66
3.029
ALA68
4.557
Residue
Distance (Å)
CYS69
2.789
ARG72
4.292
TYR116
2.704
References  Top
REF 1 Crystal structure of the human myeloid cell activating receptor TREM-1. Structure. 2003 Dec;11(12):1527-35.

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