Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T88786 Target Info
Target Name N-myc proto-oncogene protein (MYCN)
Synonyms bHLHe37; NMYC; N-myc; Class E basic helix-loop-helix protein 37
Target Type Literature-reported Target
Gene Name MYCN
UniProt ID
MYCN_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Phosphonothreonine Ligand Info
Structure Description Crystal structure of Aurora-A kinase in complex with N-Myc PDB:5G1X
Method X-ray diffraction Resolution 1.72 Å Mutation Yes [1]
PDB Sequence
LSPSRGFAEH
70
SSEPPSWVTE
80
MLLENELWG
Residue
Distance (Å)
ARG65
4.508
GLY66
3.765
Residue
Distance (Å)
PHE67
3.506
References  Top
REF 1 Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13726-13731.

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