Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T88656 | Target Info | |||
| Target Name | Notch-2 receptor (NOTCH2) | ||||
| Synonyms | hN2; Notch 2 intracellular domain; Notch 2; Neurogenic locus notch homolog protein 2 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NOTCH2 | ||||
| Biochemical Class | Notch protein | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Beta-D-Glucose | Ligand Info | |||||
| Structure Description | Human Notch-2 EGF11-13 | PDB:5MWB | ||||
| Method | X-ray diffraction | Resolution | 1.86 Å | Mutation | No | [1] |
| PDB Sequence |
DVDECAMANS
424 NPCEHAGKCV434 NTDGAFHCEC444 LKGYAGPRCE454 MDINECHSDP464 CQNDATCLDK 474 IGGFTCLCMP484 GFKGVHCELE494 INECQSNPCV504 NNGQCVDKVN514 RFQCLCPPGF 524 TGPVCQID
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| Ligand Name: alpha-L-Fucose | Ligand Info | |||||
| Structure Description | Human Notch-2 EGF11-13 | PDB:5MWB | ||||
| Method | X-ray diffraction | Resolution | 1.86 Å | Mutation | No | [1] |
| PDB Sequence |
DVDECAMANS
424 NPCEHAGKCV434 NTDGAFHCEC444 LKGYAGPRCE454 MDINECHSDP464 CQNDATCLDK 474 IGGFTCLCMP484 GFKGVHCELE494 INECQSNPCV504 NNGQCVDKVN514 RFQCLCPPGF 524 TGPVCQID
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J. 2017 Aug 1;36(15):2204-2215. | ||||
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