Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T88126 | Target Info | |||
| Target Name | Bacterial Nicotinate-nucleotide adenylyltransferase (Bact nadD) | ||||
| Synonyms | nadD of Escherichia coli (strain K12); Nicotinate mononucleotide adenylyltransferase of Escherichia coli (strain K12); NaMN adenylyltransferase of Escherichia coli (strain K12); Deamido-NAD(+)Nicotinate-nucleotide adenylyltransferase pyrophosphorylase of Escherichia coli (strain K12); Deamido-NAD(+) pyrophosphorylase of Escherichia coli (strain K12); Deamido-NAD(+) diphosphorylase of Escherichia coli (strain K12) | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | Bact nadD | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Xenon | Ligand Info | |||||
| Structure Description | Crystal structure of E. coli Nicotinic acid mononucleotide adenylyltransferase | PDB:1K4K | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
MKSLQALFGG
10 TFDPVHYGHL20 KPVETLANLI30 GLTRVTIIPN40 NVPPHRPQPE50 ANSVQRKHML 60 ELAIADKPLF70 TLDERELKRN80 APSYTAQTLK90 EWRQEQGPDV100 PLAFIIGQDS 110 LLTFPTWYEY120 ETILDNAHLI130 VCRRPGYPLE140 MAQPQYQQWL150 EDHLTHNPED 160 LHLQPAGKIY170 LAETPWFNIS180 ATIIRERLQN190 GESCEDLLPE200 PVLTYINQQG 210 LYR
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| Ligand Name: Nicotinamide-Adenine-Dinucleotide | Ligand Info | |||||
| Structure Description | Crystal structure of E.coli nicotinic acid mononucleotide adenylyltransferase complexed to deamido-NAD | PDB:1K4M | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
MKSLQALFGG
10 TFDPVHYGHL20 KPVETLANLI30 GLTRVTIIPN40 NVPPHRPQPE50 ANSVQRKHML 60 ELAIADKPLF70 TLDERELKRN80 APSYTAQTLK90 EWRQEQGPDV100 PLAFIIGQDS 110 LLTFPTWYEY120 ETILDNAHLI130 VCRRPGYPLE140 MAQPQYQQWL150 EDHLTHNPED 160 LHLQPAGKIY170 LAETPWFNIS180 ATIIRERLQN190 GESCEDLLPE200 PVLTYINQQG 210 LYR
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PHE8
3.673
GLY9
3.183
GLY10
3.362
THR11
2.907
PHE12
3.022
HIS16
3.945
GLY18
3.328
HIS19
3.595
PRO22
4.204
ILE38
4.622
ASN40
2.954
HIS45
2.836
ARG46
2.918
GLU76
4.521
SER83
4.913
TYR84
3.550
THR85
3.073
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD. Structure. 2002 Jan;10(1):69-79. | ||||
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