Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T87871 Target Info
Target Name Neurotrophic tyrosine kinase ROR1 (ROR1)
Synonyms receptor tyrosine kinase-like orphan receptor 1; receptor tyrosine kinase like orphan receptor 1; neurotrophic tyrosine kinase, receptor-related 1; dJ537F10.1; Tyrosine-protein kinase transmembrane receptor ROR1; NTRKR1; Inactive tyrosine-protein kinase transmembrane receptor ROR1
Target Type Clinical trial Target
Gene Name ROR1
Biochemical Class Kinase
UniProt ID
ROR1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Ponatinib Ligand Info
Structure Description The ROR1 Pseudokinase Domain Bound To Ponatinib PDB:6TU9
Method X-ray diffraction Resolution 1.94 Å Mutation No [1]
PDB Sequence
KPKSKAKELP
469
LSAVRFMEEL
479
GECAFGKIYK
489
GHLYLPGMDH
499
AQLVAIKTLK
509

DYNNPQQWME
519
FQQEASLMAE
529
LHHPNIVCLL
539
GAVTQEQPVC
549
MLFEYINQGD
559

LHEFLIMRSL
587
DHGDFLHIAI
597
QIAAGMEYLS
607
SHFFVHKDLA
617
ARNILIGEQL
627

HVKISDLGLS
637
REIYSADYYR
647
SLLPIRWMPP
661
EAIMYGKFSS
671
DSDIWSFGVV
681

LWEIFSFGLQ
691
PYYGFSNQEV
701
IEMVRKRQLL
711
PCSEDCPPRM
721
YSLMTECWNE
731

IPSRRPRFKD
741
IHVRLRSW
Residue
Distance (Å)
LEU479
3.942
ILE487
4.055
ALA504
3.413
ILE505
4.227
LYS506
3.865
GLU523
2.950
LEU526
3.831
MET527
3.419
LEU530
3.774
ILE535
3.887
VAL536
3.411
PHE552
3.424
GLU553
3.252
Residue
Distance (Å)
TYR554
3.385
ILE555
2.682
LEU606
3.800
PHE611
4.278
VAL612
2.711
HIS613
3.150
LYS614
3.721
LEU622
3.663
ILE631
3.258
SER632
3.439
ASP633
2.747
LEU634
4.233
References  Top
REF 1 Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases. Mol Cell. 2020 Aug 6;79(3):390-405.e7.

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