Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T86808 Target Info
Target Name Heme oxygenase 2 (HMOX2)
Synonyms HO2; HO-2
Target Type Literature-reported Target
Gene Name HMOX2
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
HMOX2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Myristic acid Ligand Info
Structure Description Crystal structure of human Heme Oxygenase-2 in complex with Myristate PDB:5UC9
Method X-ray diffraction Resolution 1.90 Å Mutation No [1]
PDB Sequence
ADLSELLKEG
40
TKEAHDRAEN
50
TQFVKDFLKG
60
NIKKELFKLA
70
TTALYFTYSA
80

LEEEMERNKD
90
HPAFAPLYFP
100
MELHRKEALT
110
KDMEYFFGEN
120
WEEQVQCPKA
130

AQKYVERIHY
140
IGQNEPELLV
150
AHAYTRYMGD
160
LSGGQVLKKV
170
AQRALKLPST
180

GEGTQFYLFE
190
NVDNAQQFKQ
200
LYRARMNALD
210
LNMKTKERIV
220
EEANKAFEYN
230

MQIFNELDQ
Residue
Distance (Å)
PHE53
3.625
VAL54
4.608
PHE57
4.418
ALA70
3.746
LEU74
3.706
THR77
4.571
TYR134
2.865
ARG156
2.896
LEU167
3.682
Residue
Distance (Å)
TYR187
4.230
ALA226
3.488
PHE227
4.784
TYR229
4.671
ASN230
2.998
ILE233
3.850
PHE234
3.543
LEU237
4.366
Ligand Name: Oxtoxynol-10 Ligand Info
Structure Description Crystal structure of human heme oxygenase-2 C127A (HO-2) PDB:2Q32
Method X-ray diffraction Resolution 2.40 Å Mutation Yes [2]
PDB Sequence
RMADLSELLK
38
EGTKEAHDRA
48
ENTQFVKDFL
58
KGNIKKELFK
68
LATTALYFTY
78

SALEEEMERN
88
KDHPAFAPLY
98
FPMELHRKEA
108
LTKDMEYFFG
118
ENWEEQVQAP
128

KAAQKYVERI
138
HYIGQNEPEL
148
LVAHAYTRYM
158
GDLSGGQVLK
168
KVAQRALKLP
178

STGEGTQFYL
188
FENVDNAQQF
198
KQLYRARMNA
208
LDLNMKTKER
218
IVEEANKAFE
228

YNMQIFNELD
238
QAG
Residue
Distance (Å)
HIS45
4.841
ALA48
3.704
GLU49
3.656
PHE53
4.587
VAL54
3.125
PHE57
3.580
ALA70
4.353
LEU74
3.495
THR77
3.939
TYR78
3.863
TYR134
3.597
Residue
Distance (Å)
HIS152
3.922
THR155
3.191
ARG156
2.703
ASP160
3.904
LEU167
3.320
PHE186
4.088
TYR187
3.354
ALA226
3.643
PHE227
3.508
ASN230
2.912
PHE234
3.326
References  Top
REF 1 Heme Oxygenase 2 Binds Myristate to Regulate Retrovirus Assembly and TLR4 Signaling. Cell Host Microbe. 2017 Feb 8;21(2):220-230.
REF 2 Comparison of apo- and heme-bound crystal structures of a truncated human heme oxygenase-2. J Biol Chem. 2007 Dec 28;282(52):37624-31.

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