Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T86552 Target Info
Target Name Tumor necrosis factor receptor type I (TNF-R1)
Synonyms p60; p55; Tumor necrosis factor-binding protein 1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNFR1; TNFR-I; TNFAR; TNF-RI; TBPI; CD120a
Target Type Clinical trial Target
Gene Name TNFRSF1A
Biochemical Class Cytokine receptor
UniProt ID
TNR1A_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 5-(3-Morpholin-4-YL-propyl)-2-(3-nitro-phenyl)-4-thioxo-4,5-dihydro-1-thia-3B,5-diaza-cyclopenta[A]pentalen-6-one Ligand Info
Structure Description PHOTOCHEMICALLY-ENHANCED BINDING OF SMALL MOLECULES TO THE TUMOR NECROSIS FACTOR RECEPTOR-1 PDB:1FT4
Method X-ray diffraction Resolution 2.90 Å Mutation No [1]
PDB Sequence
MDSVCPQGKY
20
IHPQNNSICC
30
TKCHKGTYLY
40
NDCPGPGQDT
50
DCRECESGSF
60

TASENHLRHC
70
LSCSKCRKEM
80
GQVEISSCTV
90
DRDTVCGCRK
100
NQYRHYWSEN
110

LFQCFNCSLC
120
LNGTVHLSCQ
130
EKQNTVCTCH
140
AGFFLRENEC
150
Residue
Distance (Å)
PHE60
3.791
THR61
2.744
ALA62
1.496
Residue
Distance (Å)
SER63
4.403
LEU67
3.533
LEU71
3.100
References  Top
REF 1 Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11879-84.

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