Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T86364 Target Info
Target Name Vasoactive intestinal polypeptide receptor 1 (VIPR1)
Synonyms Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide receptor-1; Vasoactive intestinal peptide receptor 1; VPAC1; VPAC-1; VIPR1; VIP-R-1; Pituitary adenylate cyclase activating polypeptide type II receptor; PACAP-R-2; PACAP type II receptor
Target Type Clinical trial Target
Gene Name VIPR1
Biochemical Class GPCR secretin
UniProt ID
VIPR1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Cholesterol Ligand Info
Structure Description Cryo-EM structure of an activated VIP1 receptor-G protein complex PDB:6VN7
Method Electron microscopy Resolution 3.20 Å Mutation No [1]
PDB Sequence
ASLDEQQTMF
138
YGSVKTGYTI
148
GYGLSLATLL
158
VATAILSLFR
168
KLHCTRNYIH
178

MHLFISFILR
188
AAAVFIKDLA
198
LFDSVGCKAA
218
MVFFQYCVMA
228
NFFWLLVEGL
238

YLYTLLAVSF
248
FSERKYFWGY
258
ILIGWGVPST
268
FTMVWTIARI
278
HFEDYGCWDT
288

INSSLWWIIK
298
GPILTSILVN
308
FILFICIIRI
318
LLQKLRPPPY
336
SRLARSTLLL
346

IPLFGVHYIM
356
FAFFPDNFKP
366
EVKMVFELVV
376
GSFQGFVVAI
386
LYCFLNGEVQ
396

AELRRKWRRW
406
HLQ
Residue
Distance (Å)
HIS180
3.361
ILE183
3.967
LEU187
3.704
SER212
4.162
VAL213
3.806
LYS216
4.445
ALA217
3.723
VAL220
4.369
PHE221
3.672
TYR224
3.572
PHE255
4.884
TRP256
4.608
ILE259
4.004
LEU260
3.939
TRP263
3.626
GLY264
3.811
SER267
3.386
PHE269
3.676
THR270
4.642
MET271
3.765
THR274
4.342
ILE278
3.616
Residue
Distance (Å)
TRP286
4.558
SER291
4.724
SER292
2.792
TRP295
3.362
ILE296
3.754
GLY299
4.880
PRO300
4.021
THR303
3.745
PHE309
4.989
PHE312
4.213
ILE313
3.759
ILE316
3.769
ARG317
3.822
LEU320
3.703
THR343
4.527
VAL352
4.951
ILE355
3.344
MET356
3.887
PHE359
4.007
PHE360
3.759
PRO361
3.739
PHE364
3.941
References  Top
REF 1 Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nat Commun. 2020 Aug 17;11(1):4121.

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