Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86062 | Target Info | |||
| Target Name | SREBP cleavage-activating protein (SCAP) | ||||
| Synonyms | SREBPcleavage-activating protein; SREBP-cleavage activating protein; SCAP | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SCAP | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 25-hydroxycholesterol | Ligand Info | |||||
| Structure Description | cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol. | PDB:6M49 | ||||
| Method | Electron microscopy | Resolution | 3.70 Å | Mutation | Yes | [1] |
| PDB Sequence |
ERLREKISRA
14 FYNHGLLCAS24 YPIPIILFTG34 FCILACCYPL44 LKLVAELIPL288 VTTYIILFAY 298 IYFSTRKIDM308 VKSKWGLALA318 AVVTVLSSLL328 MSVGLCTLFG338 LTPTLNGGEI 348 FPYLVVVIGL358 ENVLVLTKSV368 VSTPVDLEVK378 LRIAQGLSSE388 SWSIMKNMAT 398 ELGIILIGYF408 TLVPAIQEFC418 LFAVVGLVSD428 FFLQMLFFTT438 VLSIDIRRME 448 LARLAQRLIM542 AGTVVWIGIL552 VYTDPAGL
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| Ligand Name: Digitonin | Ligand Info | |||||
| Structure Description | Cryo-EM structure of Scap/Insig complex in the present of digitonin. | PDB:7ETW | ||||
| Method | Electron microscopy | Resolution | 4.10 Å | Mutation | Yes | [2] |
| PDB Sequence |
KISRAFYNHG
19 LLCASYPIPI29 ILFTGFCILA39 CCYPLLKLVD70 SDRKQGEPTE80 QPEWYVGAPV 90 AYVQQIFVKS100 SVFPWHKNLL110 AVDVFRSPLS120 RAFQLVEEIR130 NHVLRDSSGI 140 RSLEELCLQV150 TDLLPGLRKL160 RNLLPEHGCL170 LLSPGNFWQN180 DWERFHADPD 190 IIGTIHQHEP200 KTLQTSATLK210 DLLFGVPGKY220 SGVSLYTRKR230 MVSYTITLVF 240 QHYHAKFLGS250 LRARLMLLHP260 SPNCSLRAES270 LVHVHFKEEI280 GVAELIPLVT 290 TYIILFAYIY300 FSTRKIDMVK310 SKWGLALAAV320 VTVLSSLLMS330 VGLCTLFGLT 340 PTLNGGEIFP350 YLVVVIGLEN360 VLVLTKSVVS370 TPVDLEVKLR380 IAQGLSSESW 390 SIMKNMATEL400 GIILIGYFTL410 VPAIQEFCLF420 AVVGLVSDFF430 LQMLFFTTVL 440 SIDIRRMELA450 RLAQRLIMAG523 TVVWIGILVY533 TDPAGLWRKL628 SFRHWPTLFS 638 YYNITLAKRY648 ISLLPVIPVT658 LRL
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. 2021 Mar 5;371(6533):eabb2224. | ||||
| REF 2 | Structural basis for sterol sensing by Scap and Insig. doi:10.1016/j.celrep.2021.109299. | ||||
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