Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T86052 Target Info
Target Name Telomerase reverse transcriptase (TERT)
Synonyms Telomerase-associated protein 2; Telomerase catalytic subunit; TRT; TP2; TCS1; HEST2; EST2
Target Type Clinical trial Target
Gene Name TERT
Biochemical Class Kinase
UniProt ID
TERT_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Glutathione Ligand Info
Structure Description STRUCTURE OF THE HUMAN TELOMERASE THUMB DOMAIN PDB:5UGW
Method X-ray diffraction Resolution 2.31 Å Mutation No [1]
PDB Sequence
KAGRNMRRKL
974
FGVLRLKCHS
984
LFLDLQVNSL
994
QTVCTNIYKI
1004
LLLQAYRFHA
1014

CVLQLPFHQQ
1024
VWKNPTFFLR
1034
VISDTASLCY
1044
SILKAKNAGM
1054
SLGAKGAAGP
1064

LPSEAVQWLC
1074
HQAFLLKLTR
1084
HRVTYVPLLG
1094
SLRTAQTQLS
1104
RKLPGTTLTA
1114

LEAAANPA
Residue
Distance (Å)
ASN969
4.738
ARG972
3.583
LYS973
3.491
ARG979
3.995
CYS982
2.844
HIS983
3.301
PHE986
3.784
THR996
3.882
Residue
Distance (Å)
ASN1000
3.237
LYS1003
2.861
TYR1010
4.134
ARG1011
3.053
ALA1014
3.757
CYS1015
3.319
GLN1018
3.376
References  Top
REF 1 Structural Analysis Reveals the Deleterious Effects of Telomerase Mutations in Bone Marrow Failure Syndromes. J Biol Chem. 2017 Mar 17;292(11):4593-4601.

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