Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T85544 Target Info
Target Name Target of rapamycin complex 2 MAPKAP1 (MTORC2)
Synonyms mSIN1; Target of rapamycin complex 2 subunit MAPKAP1; TORC2 subunit MAPKAP1; Stress-activated map kinase-interacting protein 1; SIN1; SAPK-interacting protein 1; Mitogen-activated protein kinase 2-associated protein 1; MIP1
Target Type Clinical trial Target
Gene Name MAPKAP1
UniProt ID
SIN1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Selenomethionine Ligand Info
Structure Description Crystal Structure of KRAS4b-Q61R (GMPPNP-bound) in complex with the RAS-binding domain (RBD) of SIN1 PDB:7LC2
Method X-ray diffraction Resolution 2.70 Å Mutation Yes [1]
PDB Sequence
SLFVRINAAH
287
GFSLIQVDNT
297
KVTMKEILLK
307
AVKRRKGSQQ
322
YRLEKQSEPN
332

VAVDLDSTLE
342
SQSAWEFCLV
352
RENSSR
Residue
Distance (Å)
SER357
3.322
Residue
Distance (Å)
ARG358
3.264
References  Top
REF 1 RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity. Proc Natl Acad Sci U S A. 2021 Aug 17;118(33):e2103261118.

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