Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T85540 Target Info
Target Name Lysine-specific demethylase 5C (KDM5C)
Synonyms XE169; SMCX; Protein Xe169; Protein SmcX; Jumonji/ARID domain-containing protein 1C; JARID1C; Histone demethylase JARID1C; DXS1272E
Target Type Literature-reported Target
Gene Name KDM5C
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
KDM5C_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 2-{[(2-{[(E)-2-(Dimethylamino)ethenyl](Ethyl)amino}-2-Oxoethyl)amino]methyl}pyridine-4-Carboxylic Acid Ligand Info
Structure Description Crystal structure of human JARID1C in complex with KDM5-C49 PDB:5FWJ
Method X-ray diffraction Resolution 2.10 Å Mutation No [1]
PDB Sequence
SMFLPPPECP
15
VFEPSWAEFR
25
DPLGYIAKIR
35
PIAEKSGICK
45
IRPPADWQPP
55

FAVEVDNFRF
65
TPRIQRLNEL
75
TREYTLQSFG
398
EMADSFKADY
408
FNMPVHMVPT
418

ELVEKEFWRL
428
VNSIEEDVTV
438
EYGADIHSKE
448
FGSGFPVSDS
458
KRHLTPEEEE
468

YATSGWNLNV
478
MPVLEQSVLC
488
HINADISGMK
498
VPWLYVGMVF
508
SAFCWHIEDH
518

WSYSINYLHW
528
GEPKTWYGVP
538
SLAAEHLEEV
548
MKKLTLMNPN
574
TLMSHGVPVV
584

RTNQCAGEFV
594
ITFPRAYHSG
604
FNQGYNFAEA
614
VNFCTADWLP
624
AGRQCIEHYR
634

RLRRYCVFSH
644
EELICKMAAC
654
PEKLDLNLAA
664
AVHKEMFIMV
674
QEERRLRKAL
684

LEKGITEAER
694
EAFELLPDDE
704
RQCIKCKTTC
714
FLSALACYDC
724
PDGLVCLSHI
734

NDLCKCSSSR
744
QYLRYRYTLD
754
ELPAMLHKLK
764
VRAES
Residue
Distance (Å)
TYR440
2.475
ASP443
3.322
GLY496
3.590
TRP501
3.381
TYR503
3.148
PHE511
3.431
HIS514
2.767
GLU516
3.121
Residue
Distance (Å)
SER522
4.623
ASN524
3.637
LYS532
2.736
TRP534
3.403
HIS602
3.373
ALA614
3.778
VAL615
3.576
ASN616
3.646
References  Top
REF 1 Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12(7):539-45.

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