Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T85426 Target Info
Target Name Hepatitis B virus Capsid protein (HBV C)
Synonyms Core antigen; Core protein; HBcAg; p21.5
Target Type Clinical trial Target
Gene Name HBV C
UniProt ID
CAPSD_HBVD3
Drug Binding Sites of Target  Top
Ligand Name: 1-{2-[2-(2-Methoxyethoxy)ethoxy]ethoxy}-4-(1,1,3,3-tetramethylbutyl)benzene Ligand Info
Structure Description HBc-F97L premature secretion phenotype PDB:7PZL
Method Electron microscopy Resolution 2.80 Å Mutation Yes [1]
PDB Sequence
MDIDPYKEFG
10
ATVELLSFLP
20
SDFFPSVRDL
30
LDTASALYRE
40
ALESPEHCSP
50

HHTALRQAIV
60
CWGELMTLAT
70
WVGVNLEDPA
80
SRDLVVSYVN
90
TNMGLKFRQL
100

LWFHISCLTF
110
GRETVIEYLV
120
SFGVWIRTPP
130
AYRPPNAPIL
140
STL
Residue
Distance (Å)
PRO5
4.567
TYR6
3.869
VAL13
3.971
ALA58
3.388
CYS61
3.988
TRP62
3.710
LEU65
3.292
Residue
Distance (Å)
ASN92
3.660
MET93
2.902
LEU95
3.362
LYS96
2.903
PHE97
3.632
GLN99
2.792
LEU100
3.535
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References  Top
REF 1 Binding of a Pocket Factor to Hepatitis B Virus Capsids Changes the Rotamer Conformation of Phenylalanine 97. Viruses. 2021 Oct 20;13(11):2115.

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