Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85241 | Target Info | |||
| Target Name | Cell division cycle protein 20 homolog (CDC20) | ||||
| Synonyms | p55CDC | ||||
| Target Type | Preclinical Target | ||||
| Gene Name | CDC20 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-(2-Methyl-5-Nitro-1h-Imidazol-1-Yl)ethyl [(1r)-2,2,2-Trichloro-1-(Pyrimidin-2-Ylamino)ethyl]carbamate | Ligand Info | |||||
| Structure Description | Crystal structure of Cdc20 and apcin complex | PDB:4N14 | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
CRYIPSLPDR
174 ILDAPEIRND184 YYLNLVDWSS194 GNVLAVALDN204 SVYLWSASSG214 DILQLLQMEQ 224 PGEYISSVAW234 IKEGNYLAVG244 TSSAEVQLWD254 VQQQKRLRNM264 TSHSARVGSL 274 SWNSYILSSG284 SRSGHIHHHD294 VRVAEHHVAT304 LSGHSQEVCG314 LRWAPDGRHL 324 ASGGNDNLVN334 VWPSAPGEGG344 WVPLQTFTQH354 QGAVKAVAWC364 PWQSNVLATG 374 GGTSDRHIRI384 WNVCSGACLS394 AVDAHSQVCS404 ILWSPHYKEL414 ISGHGFAQNQ 424 LVIWKYPTMA434 KVAELKGHTS444 RVLSLTMSPD454 GATVASAAAD464 ETLRLWRCFE 474 LDP
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature. 2014 Oct 30;514(7524):646-9. | ||||
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