Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T84439 | Target Info | |||
| Target Name | G-protein-coupled receptor PGR3 (GPR139) | ||||
| Synonyms | Probable G-protein coupled receptor 139; PGR3; GPRG1; G(q)-coupled orphan receptor GPRg1 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | GPR139 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 3-chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide | Ligand Info | |||||
| Structure Description | Cryo-EM structure of a class A orphan GPCR in complex with Gi | PDB:7VUG | ||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | Yes | [1] |
| PDB Sequence |
CGLGFVPVVY
32 YSLLLCLGLP42 ANILTVIILS52 QLVARRQKSV62 YNYLLALAAA72 DILVLFFIVF 82 VDFLLEDFIL92 NMQMPQVPDK102 IIEVLEFSSI112 HTSIWITVPL122 TIDRYIAVCH 132 PLKYHTVSYP142 ARTRKVIVSV152 YITCFLTSIP162 YYWWPNIWTE172 DYISTSVHHV 182 LIWIHCFTVY192 LVPCSIFFIL202 NSIIVYKLRR212 KSNFRLRGYS222 TGKTTAILFT 232 ITSIFATLWA242 PRIIMILYHL252 YGAPIQNRWL262 VHIMSDIANM272 LALLNTAINF 282 FLYCFISKRF292 RTMAAATLKA302 FF
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res. 2022 Feb;32(2):210-213. | ||||
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