Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83905 | Target Info | |||
| Target Name | Placental cadherin (CDH3) | ||||
| Synonyms | Pcadherin; P-cadherin; Cadherin-3; CDHP | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CDH3 | ||||
| Biochemical Class | Cadherin protein | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-(5-chloro-2-methyl-1H-indol-3-yl)ethanamine | Ligand Info | |||||
| Structure Description | Crystal structure of human P-cadherin REC12 (monomer) in complex with 2-(5-chloro-2-methyl-1H-indol-3-yl)ethan-1-amine (inhibitor) | PDB:7CMF | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
WVVAPISVPE
11 NGKGPFPQRL21 NQLKSNKDRD31 TKIFYSITGP41 GADSPPEGVF51 AVEKETGWLL 61 LNKPLDREEI71 AKYELFGHAV81 SENGASVEDP91 MNISIIVTDQ101 NDHKPKFTQD 111 TFRGSVLEGV121 LPGTSVMQVT131 ATDEDDAIYT141 YNGVVAYSIH151 SQEPKDPHDL 161 MFTIHRSTGT171 ISVISSGLDR181 EKVPEYTLTI191 QATDMDGDGS201 TTTAVAVVEI 211 LD
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion. doi:10.1038/s42003-021-02575-3. | ||||
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