Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T83284 Target Info
Target Name Quinone oxidoreductase (CRYZ)
Synonyms Zeta-crystallin; NADPH:quinone reductase; CRYZ
Target Type Literature-reported Target
Gene Name CRYZ
UniProt ID
QOR_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: NADP+ Ligand Info
Structure Description Crystal structure of human Zeta-Crystallin with bound NADP PDB:1YB5
Method X-ray diffraction Resolution 1.85 Å Mutation No [1]
PDB Sequence
KLMRAVRVFE
15
FGGPEVLKLR
25
SDIAVPIPKD
35
HQVLIKVHAC
45
GVNPVETYIR
55

SGTYSRKPLL
65
PYTPGSDVAG
75
VIEAVGDNAS
85
AFKKGDRVFT
95
SSTISGGYAE
105

YALAADHTVY
115
KLPEKLDFKQ
125
GAAIGIPYFT
135
AYRALIHSAC
145
VKAGESVLVH
155

GASGGVGLAA
165
CQIARAYGLK
175
ILGTAGTEEG
185
QKIVLQNGAH
195
EVFNHREVNY
205

IDKIKKYVGE
215
KGIDIIIEML
225
ANVNLSKDLS
235
LLSHGGRVIV
245
VGSRGTIEIN
255

PRDTMAKESS
265
IIGVTLFSST
275
KEEFQQYAAA
285
LQAGMEIGWL
295
KPVIGSQYPL
305

EKVAEAHENI
315
IHGSGATGKM
325
ILLL
Residue
Distance (Å)
ASN48
4.602
PRO49
3.298
VAL50
4.284
TYR53
2.708
ILE131
3.325
THR135
3.182
HIS155
3.683
GLY156
3.179
ALA157
3.817
SER158
2.744
GLY159
2.994
GLY160
2.966
VAL161
2.941
GLY162
4.021
THR179
4.328
ALA180
3.521
GLY181
2.786
THR182
4.361
HIS200
2.820
ARG201
3.861
Residue
Distance (Å)
TYR205
4.582
GLU223
4.298
MET224
3.829
LEU225
3.615
VAL228
4.283
ASN229
2.874
VAL245
4.627
VAL246
2.911
GLY247
3.719
SER248
4.510
ARG249
3.396
VAL269
2.842
THR270
3.295
LEU271
2.820
PHE272
4.896
ILE315
3.409
GLY320
3.340
ALA321
2.738
GLY323
4.663
References  Top
REF 1 Crystal Structure of human Zeta-Crystallin at 1.85A

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