Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83196 | Target Info | |||
| Target Name | PC4 and SFRS1-interacting protein (PSIP1) | ||||
| Synonyms | Transcriptional coactivator p75/p52; PSIP2; Lens epithelium-derived growth factor; LEDGF; Dense fine speckles 70 kDa protein; DFS70; DFS 70; CLL-associated antigen KW-7 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | PSIP1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Glyoxalate, Glyoxylate | Ligand Info | |||||
| Structure Description | Crystal structure of human menin in complex with MLL1 and LEDGF | PDB:3U88 | ||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
MDSRLQRIHA
357 EIKNSLKIDN367 LDVNRCIEAL377 DELASLQVTM387 QQAQKHTEMI397 TTLKKIRRFK 407 VSQVIMEKST417 MLYNKFKNMF427 LV
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| Ligand Name: L-2-Amino-4-(Guanidinooxy)Butyric Acid | Ligand Info | |||||
| Structure Description | Crystal structure of human menin in complex with MLL1 and LEDGF | PDB:3U88 | ||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
MDSRLQRIHA
357 EIKNSLKIDN367 LDVNRCIEAL377 DELASLQVTM387 QQAQKHTEMI397 TTLKKIRRFK 407 VSQVIMEKST417 MLYNKFKNMF427 LV
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature. 2012 Feb 12;482(7386):542-6. | ||||
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