Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T82383 Target Info
Target Name Tyrosine-protein kinase UFO (AXL)
Synonyms UFO; Tyrosine-protein kinase receptor UFO; AXL oncogene
Target Type Successful Target
Gene Name AXL
Biochemical Class Kinase
UniProt ID
UFO_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: (10r)-7-Amino-11-Chloro-12-Fluoro-1-(2-Hydroxyethyl)-3,10,16-Trimethyl-16,17-Dihydro-1h-8,4-(Azeno)pyrazolo[4,3-H][2,5,11]benzoxadiazacyclotetradecin-15(10h)-One Ligand Info
Structure Description Structure of the Axl kinase domain in complex with a macrocyclic inhibitor PDB:5U6B
Method X-ray diffraction Resolution 2.84 Å Mutation No [1]
PDB Sequence
ELKEKLRDVM
530
VDRHKVALGK
540
TLGEGEFGAV
550
MEGQLNQDDS
560
ILKVAVKTMK
570

IAICTRSELE
580
DFLSEAVCMK
590
EFDHPNVMRL
600
IGVCFQPAPV
617
VILPFMKHGD
627

LHSFLLYSRL
637
GDQPVYLPTQ
647
MLVKFMADIA
657
SGMEYLSTKR
667
FIHRDLAARN
677

CMLNENMSVC
687
VADFGLSKPV
713
KWIAIESLAD
723
RVYTSKSDVW
733
SFGVTMWEIA
743

TRGQTPYPGV
753
ENSEIYDYLR
763
QGNRLKQPAD
773
CLDGLYALMS
783
RCWELNPQDR
793

PSFTELREDL
803
ENTLKALPPA
813
Residue
Distance (Å)
LEU542
3.528
GLY543
4.030
VAL550
3.324
ALA565
3.296
LYS567
3.819
MET598
3.399
LEU620
3.624
PRO621
2.749
PHE622
3.598
MET623
3.045
Residue
Distance (Å)
LYS624
4.318
GLY626
3.432
ASP627
2.695
SER630
3.863
ARG676
3.121
ASN677
3.542
CYS678
4.104
MET679
3.466
ALA689
3.459
ASP690
4.481
References  Top
REF 1 The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase. J Biol Chem. 2017 Sep 22;292(38):15705-15716.

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