Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T82297 | Target Info | |||
| Target Name | Folate receptor beta (FOLR2) | ||||
| Synonyms | Placental folate-binding protein; Folate receptor, fetal/placental; Folate receptor type-beta; Folate receptor 2; FR-beta; FOLR2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | FOLR2 | ||||
| Biochemical Class | Folate receptor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Methotrexate | Ligand Info | |||||
| Structure Description | Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate | PDB:4KN0 | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
RTDLLNVCMD
33 AKHHKTKPGP43 EDKLHDQCSP53 WKKNACCTAS63 TSQELHKDTS73 RLYNFNWDHC 83 GKMEPACKRH93 FIQDTCLYEC103 SPNLGPWIQQ113 VNQSWRKERF123 LDVPLCKEDC 133 QRWWEDCHTS143 HTCKSNWHRG153 WDWTSGVNKC163 PAGALCRTFE173 SYFPTPAALC 183 EGLWSHSYKV193 SNYSRGSGRC203 IQMWFDSAQG213 NPNEEVARFY223 AAAMH |
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| Ligand Name: Folic acid | Ligand Info | |||||
| Structure Description | Human folate receptor beta (FOLR2) in complex with the folate | PDB:4KMZ | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
TDLLNVCMDA
34 KHHKTKPGPE44 DKLHDQCSPW54 KKNACCTAST64 SQELHKDTSR74 LYNFNWDHCG 84 KMEPACKRHF94 IQDTCLYECS104 PNLGPWIQQV114 NQSWRKERFL124 DVPLCKEDCQ 134 RWWEDCHTSH144 TCKSNWHRGW154 DWTSGVNKCP164 AGALCRTFES174 YFPTPAALCE 184 GLWSHSYKVS194 NYSRGSGRCI204 QMWFDSAQGN214 PNEEVARFYA224 AAM |
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| Ligand Name: Pemetrexed | Ligand Info | |||||
| Structure Description | Human folate receptor beta (FOLR2) in complex with antifolate pemetrexed | PDB:4KN2 | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
TDLLNVCMDA
34 KHHKTKPGPE44 DKLHDQCSPW54 KKNACCTAST64 SQELHKDTSR74 LYNFNWDHCG 84 KMEPACKRHF94 IQDTCLYECS104 PNLGPWIQQV114 NQSWRKERFL124 DVPLCKEDCQ 134 RWWEDCHTSH144 TCKSNWHRGW154 DWTSGVNKCP164 AGALCRTFES174 YFPTPAALCE 184 GLWSHSYKVS194 NYSRGSGRCI204 QMWFDSAQGN214 PNEEVARFYA224 AA |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LYA or .LYA2 or .LYA3 or :3LYA;style chemicals stick;color identity;select .A:76 or .A:78 or .A:80 or .A:97 or .A:98 or .A:101 or .A:116 or .A:117 or .A:118 or .A:119 or .A:123 or .A:150 or .A:151 or .A:152 or .A:153 or .A:154 or .A:156 or .A:187 or .A:190 or .A:191; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Aminopterin | Ligand Info | |||||
| Structure Description | Human folate receptor beta (FOLR2) in complex with the antifolate aminopterin | PDB:4KN1 | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
RTDLLNVCMD
33 AKHHKTKPGP43 EDKLHDQCSP53 WKKNACCTAS63 TSQELHKDTS73 RLYNFNWDHC 83 GKMEPACKRH93 FIQDTCLYEC103 SPNLGPWIQQ113 VNQSWRKERF123 LDVPLCKEDC 133 QRWWEDCHTS143 HTCKSNWHRG153 WDWTSGVNKC163 PAGALCRTFE173 SYFPTPAALC 183 EGLWSHSYKV193 SNYSRGSGRC203 IQMWFDSAQG213 NPNEEVARFY223 AAAMH |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .04J or .04J2 or .04J3 or :304J;style chemicals stick;color identity;select .A:76 or .A:78 or .A:97 or .A:98 or .A:101 or .A:116 or .A:117 or .A:118 or .A:119 or .A:123 or .A:150 or .A:151 or .A:152 or .A:153 or .A:154 or .A:156 or .A:187 or .A:190; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15180-8. | ||||
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